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ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans

dc.contributor.authorBoekstegers F.
dc.contributor.authorMarcelain K.
dc.contributor.authorBarahona Ponce C.
dc.contributor.authorBaez Benavides P.F.
dc.contributor.authorMüller B.
dc.contributor.authorde Toro G.
dc.contributor.authorRetamales J.
dc.contributor.authorBarajas O.
dc.contributor.authorAhumada M.
dc.contributor.authorMorales E.
dc.contributor.authorRojas A.
dc.contributor.authorSanhueza V.
dc.contributor.authorLoader D.
dc.contributor.authorRivera M.T.
dc.contributor.authorGutiérrez L.
dc.contributor.authorBernal G.
dc.contributor.authorOrtega A.
dc.contributor.authorMontalvo D.
dc.contributor.authorPortiño S.
dc.contributor.authorBertrán M.E.
dc.contributor.authorGabler F.
dc.contributor.authorSpencer L.
dc.contributor.authorOlloquequi J.
dc.contributor.authorGonzález Silos R.
dc.contributor.authorFischer C.
dc.contributor.authorScherer D.
dc.contributor.authorJenab M.
dc.contributor.authorAleksandrova K.
dc.contributor.authorKatzke V.
dc.contributor.authorWeiderpass E.
dc.contributor.authorMoradi T.
dc.contributor.authorFischer K.
dc.contributor.authorBossers W.
dc.contributor.authorBrenner H.
dc.contributor.authorHveem K.
dc.contributor.authorEklund N.
dc.contributor.authorVölker U.
dc.contributor.authorWaldenberger M.
dc.contributor.authorFuentes Guajardo M.
dc.contributor.authorGonzalez-Jose R.
dc.contributor.authorBedoya G.
dc.contributor.authorBortolini M.C.
dc.contributor.authorCanizales S.
dc.contributor.authorGallo C.
dc.contributor.authorRuiz Linares A.
dc.contributor.authorRothhammer F.
dc.contributor.authorLorenzo Bermejo J.
dc.date.accessioned2020-09-02T22:13:31Z
dc.date.available2020-09-02T22:13:31Z
dc.date.issued2020
dc.identifier10.1016/j.canep.2019.101643
dc.identifier.citation65, , -
dc.identifier.issn18777821
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3770
dc.descriptionBackground: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. © 2020 The Authors
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectCancer epidemiology
dc.subjectGallbladder cancer
dc.subjectNative American ancestry
dc.subjectPopulation-specific risk marker
dc.subjectmultidrug resistance protein 1
dc.subjectmultidrug resistance protein 4
dc.subjectadult
dc.subjectaged
dc.subjectAmerican Indian
dc.subjectArticle
dc.subjectcancer incidence
dc.subjectcancer risk
dc.subjectcase control study
dc.subjectChilean
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectethnic difference
dc.subjectEuropean
dc.subjectfemale
dc.subjectgallbladder cancer
dc.subjectgene frequency
dc.subjectgenetic variability
dc.subjectgenome-wide association study
dc.subjectgenotype
dc.subjecthuman
dc.subjectIndia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpopulation research
dc.subjectprincipal component analysis
dc.subjectpriority journal
dc.titleABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
dc.typeArticle


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