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A review of the pharmacological and therapeutic effects of auraptene

dc.contributor.authorBibak B.
dc.contributor.authorShakeri F.
dc.contributor.authorBarreto G.E.
dc.contributor.authorKeshavarzi Z.
dc.contributor.authorSathyapalan T.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:13:10Z
dc.date.available2020-09-02T22:13:10Z
dc.date.issued2019
dc.identifier10.1002/biof.1550
dc.identifier.citation45, 6, 867-879
dc.identifier.issn09516433
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3758
dc.descriptionThere is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the therapeutic benefits of auraptene. Auraptene, also known as auraptene and 7-geranyloxycoumarin, is a bioactive monoterpene coumarin from Rutaceae family, which is isolated from Citrus aurantium (Seville orange) and Aegle marmelos (bael fruit). Auraptene is a highly pleiotropic molecule, which can modulate intracellular signaling pathways that control inflammation, cell growth, and apoptosis. It has a potential therapeutic role in the prevention and treatment of various diseases due to its anti-inflammatory and antioxidant activities as well as its excellent safety profile. In the present article, various pharmacological and therapeutic effects of auraptene were reviewed. Different online databases using keywords such as auraptene, therapeutic effects and pharmacological effects were searched until the end of September 2018, for this purpose. Auraptene has been suggested to be effective in the treatment of a broad range of disorders including inflammatory disorders, dysentery, wounds, scars, keloids, and pain. In addition, different studies have demonstrated that auraptene possesses numerous pharmacological properties including anti-inflammatory, anti-oxidative, anti-diabetic, anti-hypertensive and anti-cancer as well as neuroprotective effects. The present review provides a detailed survey of scientific researches regarding pharmacological properties and therapeutic effects of auraptene. © 2019 International Union of Biochemistry and Molecular Biology
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.subjectauraptene
dc.subjectchemopreventive
dc.subjectpharmacological properties
dc.subjectauraptene
dc.subjectcisplatin
dc.subjectfluorouracil
dc.subjectnifedipine
dc.subjectpaclitaxel
dc.subjectantiinflammatory agent
dc.subjectauraptene
dc.subjectcoumarin
dc.subjectcoumarin derivative
dc.subjectaberrant crypt focus
dc.subjectAegle marmelos
dc.subjectantidiabetic activity
dc.subjectantihypertensive activity
dc.subjectantiinflammatory activity
dc.subjectantineoplastic activity
dc.subjectantioxidant activity
dc.subjectapoptosis
dc.subjectcardiovascular system
dc.subjectcell growth
dc.subjectcell viability
dc.subjectcholestasis
dc.subjectdata base
dc.subjectdrug cytotoxicity
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug potentiation
dc.subjectdrug safety
dc.subjectdysentery
dc.subjectG2 phase cell cycle checkpoint
dc.subjectgastrointestinal tract
dc.subjecthuman
dc.subjectimmune system
dc.subjectinflammatory disease
dc.subjectintracellular signaling
dc.subjectliver injury
dc.subjectmalignant neoplasm
dc.subjectMedline
dc.subjectmild cognitive impairment
dc.subjectnervous system
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectpain
dc.subjectpriority journal
dc.subjectReview
dc.subjectRutaceae
dc.subjectscar
dc.subjectScopus
dc.subjectsour orange
dc.subjectWeb of Science
dc.subjectwound
dc.subjectAegle
dc.subjectcell proliferation
dc.subjectchemistry
dc.subjectCitrus
dc.subjectinflammation
dc.subjectsignal transduction
dc.subjectAegle
dc.subjectAnti-Inflammatory Agents
dc.subjectApoptosis
dc.subjectCell Proliferation
dc.subjectCitrus
dc.subjectCoumarins
dc.subjectHumans
dc.subjectInflammation
dc.subjectSignal Transduction
dc.titleA review of the pharmacological and therapeutic effects of auraptene
dc.typeReview


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