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Six-month follow-up of the effect of nonvital bleaching on IL-1b and RANK-L: A randomized clinical trial

dc.contributor.authorBersezio C.
dc.contributor.authorEstay J.
dc.contributor.authorSáez M.
dc.contributor.authorSánchez F.
dc.contributor.authorVernal R.
dc.contributor.authorFernández E.
dc.date.accessioned2020-09-02T22:13:08Z
dc.date.available2020-09-02T22:13:08Z
dc.date.issued2019
dc.identifier10.2341/18-023-C
dc.identifier.citation44, 6, 581-588
dc.identifier.issn03617734
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3744
dc.descriptionObjectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1b biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical ‘‘walking bleach’’ over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1b and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (DSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1b and RANK-L across time points was detected (p,0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p,0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (.0.8) between the IL-1b and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1b and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points. © 2019 Indiana University School of Dentistry. All rights reserved.
dc.language.isoen
dc.publisherIndiana University School of Dentistry
dc.titleSix-month follow-up of the effect of nonvital bleaching on IL-1b and RANK-L: A randomized clinical trial
dc.typeArticle


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