Mostrar el registro sencillo del ítem

The voltage-gated T-type Ca2+ channel is key to the sperm motility of Atlantic salmon (Salmo salar)

dc.contributor.authorBeltrán J.F.
dc.contributor.authorBelén L.H.
dc.contributor.authorLee-Estevez M.
dc.contributor.authorFigueroa E.
dc.contributor.authorDumorné K.
dc.contributor.authorFarias J.G.
dc.date.accessioned2020-09-02T22:13:04Z
dc.date.available2020-09-02T22:13:04Z
dc.date.issued2020
dc.identifier10.1007/s10695-020-00829-1
dc.identifier.citation46, 5, 1825-1831
dc.identifier.issn09201742
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3723
dc.descriptionCa2+ is a key element in the sperm activation process of Salmo salar. However, the molecular mechanisms by which this ion enters the sperm cell have been poorly studied. In this study, we examined, for the first time, the role of the voltage-gated T-type Ca2+ channel in the activation of sperm motility of Salmo salar. Using an in vitro inhibition assay, a significant decrease in total and progressive motility (P < 0.0001) was observed in Salmo salar sperm when they were treated with NNC-55-0396, a highly selective blocker. The in silico analysis showed that this blocker is docked with a strong affinity for the pore of the voltage-gated T-type calcium channel suggesting the blocking of Ca2+ ions. The results show that the T-type voltage-gated Ca2+ channel is key to sperm motility in Salmo salar. © 2020, Springer Nature B.V.
dc.language.isoen
dc.publisherSpringer
dc.subjectIn silico
dc.subjectMotility
dc.subjectNNC 55-0396
dc.subjectSalmo salar
dc.subjectVoltage-gated Ca2+ channels T-type
dc.titleThe voltage-gated T-type Ca2+ channel is key to the sperm motility of Atlantic salmon (Salmo salar)
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85085984219.pdf
Tamaño:
2.004Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem