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Assessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System

dc.contributor.authorBellolio E.
dc.contributor.authorRiquelme I.
dc.contributor.authorRiffo-Campos A.L.
dc.contributor.authorRueda C.
dc.contributor.authorFerreccio C.
dc.contributor.authorVillaseca M.
dc.contributor.authorBrebi P.
dc.contributor.authorMuñoz S.
dc.contributor.authorAraya J.C.
dc.date.accessioned2020-09-02T22:13:04Z
dc.date.available2020-09-02T22:13:04Z
dc.date.issued2019
dc.identifier10.1007/s12253-018-0532-3
dc.identifier.citation25, 3, 1135-1142
dc.identifier.issn12194956
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3722
dc.descriptionGastric cancer (GC) is the first cancer-related cause of death in Chile; however, no plan for GC early detection has been implemented in this country. The OLGA system characterizes gastritis from stages 0 to IV according to the risk of developing GC based on H. pylori infection, atrophy, metaplasia and GC. In this study, the performance of the OLGA system was evaluated in 485 Chilean patients receiving routine endoscopy to improve the detection of early GC or preneoplastic lesions. The results showed that OLGA scores, atrophy, metaplasia and GC increased significantly with age (p < 0.001). Conversely, H. pylori infection was higher in younger groups (p < 0.05). All gastric lesions were more frequent in men than women. The majority of patients with atrophy also had metaplasia (99%, p < 0.0001). Patients with H. pylori infection had more gastric atrophy and metaplasia than those without infection (p < 0.05). Of the 485 patients, 21 (4.3%) had GC, being 2.3 times more frequent among men than women and about 2/3 (14) were in OLGA stage ≥2. In addition, 19 (90%) GC patients had atrophy and 18 (85%) had metaplasia (p < 0.001). In conclusion, the OLGA system facilitated the evaluation of GC precursor lesions particularly in patients with an OLGA score > 2 between 45 and 56 years old, because this group showed atrophy and intestinal metaplasia more frequently. Therefore, biennial endoscopic surveillance of patients with an OLGA >2 can be an important health policy in Chile for diagnosing GC in its early stages and reducing mortality over the next two decades. © 2018, Arányi Lajos Foundation.
dc.language.isoen
dc.publisherSpringer Netherlands
dc.subjectChilean population
dc.subjectGastric atrophy
dc.subjectGastric cancer
dc.subjectHelicobacter pylori infection
dc.subjectMetaplasia
dc.subjectThe OLGA system
dc.subjectadolescent
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectArticle
dc.subjectcancer diagnosis
dc.subjectcancer patient
dc.subjectcancer risk
dc.subjectcancer staging
dc.subjectChilean
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdescriptive research
dc.subjectdisease severity
dc.subjectearly cancer
dc.subjectendoscopy
dc.subjectfemale
dc.subjectgastritis
dc.subjectHelicobacter infection
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetaplasia
dc.subjectmiddle aged
dc.subjectnonhuman
dc.subjectOLGA system
dc.subjectprecancer
dc.subjectrisk assessment
dc.subjectscoring system
dc.subjectsex difference
dc.subjectstomach atrophy
dc.subjectstomach cancer
dc.subjectyoung adult
dc.subjectcomplication
dc.subjectearly cancer diagnosis
dc.subjectfollow up
dc.subjectgastritis
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjectisolation and purification
dc.subjectmetaplasia
dc.subjectpathology
dc.subjectprecancer
dc.subjectprocedures
dc.subjectprognosis
dc.subjectrisk factor
dc.subjectseverity of illness index
dc.subjectstomach tumor
dc.subjectvery elderly
dc.subjectvirology
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCross-Sectional Studies
dc.subjectEarly Detection of Cancer
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGastritis
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectMale
dc.subjectMetaplasia
dc.subjectMiddle Aged
dc.subjectPrecancerous Conditions
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectStomach Neoplasms
dc.subjectYoung Adult
dc.titleAssessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System
dc.typeArticle


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