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Antibacterial activities of azole complexes combined with silver nanoparticles

dc.contributor.authorBello-Vieda N.J.
dc.contributor.authorPastrana H.F.
dc.contributor.authorGaravito M.F.
dc.contributor.authorÁvila A.G.
dc.contributor.authorCelis A.M.
dc.contributor.authorMuñoz-Castro A.
dc.contributor.authorRestrepo S.
dc.contributor.authorHurtado J.J.
dc.date.accessioned2020-09-02T22:13:04Z
dc.date.available2020-09-02T22:13:04Z
dc.date.issued2018
dc.identifier10.3390/molecules23020361
dc.identifier.citation23, 2, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3721
dc.descriptionGrowing antimicrobial resistance is considered a potential threat for human health security by health organizations, such as the WHO, CDC and FDA, pointing to MRSA as an example. New antibacterial drugs and complex derivatives are needed to combat the development of bacterial resistance. Six new copper and cobalt complexes of azole derivatives were synthesized and isolated as air-stable solids and characterized by melting point analyses, elemental analyses, thermogravimetric analyses (TGA), and infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that the complexes had 1:1 (M:L) stoichiometries and tetrahedral geometries, the latter being supported by DFT calculations. The antibacterial activities of the metal complexes by themselves and combined with silver nanoparticles (AgNPs; 2 -g mL-1) were assessed in vitro by broth microdilution assays against eight bacterial strains of clinical relevance. The results showed that the complexes alone exhibited moderate antibacterial activities. However, when the metal complexes were combined with AgNPs, their antibacterial activities increased (up to 10-fold in the case of complex 5), while human cell viabilities were maintained. The minimum inhibitory concentration (MIC50) values were in the range of 25-500 -g mL-1. This study thus presents novel approaches for the design of materials for fighting bacterial resistance. The use of azole complexes combined with AgNPs provides a new alternative against bacterial infections, especially when current treatments are associated with the rapid development of antibiotic resistance. © 2018 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntibacterial activity
dc.subjectAntibacterial resistance
dc.subjectAzole ligands
dc.subjectCopper and cobalt complexes
dc.subjectCytotoxicity
dc.subjectSilver nanoparticles
dc.subjectantiinfective agent
dc.subjectcobalt
dc.subjectcopper
dc.subjectligand
dc.subjectmetal nanoparticle
dc.subjectpyrrole derivative
dc.subjectsilver
dc.subjectatomic force microscopy
dc.subjectbacterium
dc.subjectcell survival
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectcolloid
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmicrobial sensitivity test
dc.subjectmolecular model
dc.subjectspectroscopy
dc.subjectthermogravimetry
dc.subjectAnti-Bacterial Agents
dc.subjectAzoles
dc.subjectBacteria
dc.subjectCell Survival
dc.subjectCobalt
dc.subjectColloids
dc.subjectCopper
dc.subjectHumans
dc.subjectLigands
dc.subjectMetal Nanoparticles
dc.subjectMicrobial Sensitivity Tests
dc.subjectMicroscopy, Atomic Force
dc.subjectModels, Molecular
dc.subjectMolecular Structure
dc.subjectSilver
dc.subjectSpectrum Analysis
dc.subjectThermogravimetry
dc.titleAntibacterial activities of azole complexes combined with silver nanoparticles
dc.typeArticle


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