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TASK Channels Pharmacology: New Challenges in Drug Design

dc.contributor.authorBedoya M.
dc.contributor.authorRinné S.
dc.contributor.authorKiper A.K.
dc.contributor.authorDecher N.
dc.contributor.authorGonzález W.
dc.contributor.authorRamírez D.
dc.date.accessioned2020-09-02T22:13:04Z
dc.date.available2020-09-02T22:13:04Z
dc.date.issued2019
dc.identifier10.1021/acs.jmedchem.9b00248
dc.identifier.citation62, 22, 10044-10058
dc.identifier.issn00222623
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3719
dc.descriptionRational drug design targeting ion channels is an exciting and always evolving research field. New medicinal chemistry strategies are being implemented to explore the wild chemical space and unravel the molecular basis of the ion channels modulators binding mechanisms. TASK channels belong to the two-pore domain potassium channel family and are modulated by extracellular acidosis. They are extensively distributed along the cardiovascular and central nervous systems, and their expression is up- and downregulated in different cancer types, which makes them an attractive therapeutic target. However, TASK channels remain unexplored, and drugs designed to target these channels are poorly selective. Here, we review TASK channels properties and their known blockers and activators, considering the new challenges in ion channels drug design and focusing on the implementation of computational methodologies in the drug discovery process. © 2019 American Chemical Society.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.titleTASK Channels Pharmacology: New Challenges in Drug Design
dc.typeReview


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