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NeuroMuscleDB: a Database of Genes Associated with Muscle Development, Neuromuscular Diseases, Ageing, and Neurodegeneration

dc.contributor.authorBaig M.H.
dc.contributor.authorRashid I.
dc.contributor.authorSrivastava P.
dc.contributor.authorAhmad K.
dc.contributor.authorJan A.T.
dc.contributor.authorRabbani G.
dc.contributor.authorChoi D.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAshraf G.M.
dc.contributor.authorLee E.J.
dc.contributor.authorChoi I.
dc.date.accessioned2020-09-02T22:13:03Z
dc.date.available2020-09-02T22:13:03Z
dc.date.issued2019
dc.identifier10.1007/s12035-019-1478-5
dc.identifier.citation56, 8, 5835-5843
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3715
dc.descriptionSkeletal muscle is a highly complex, heterogeneous tissue that serves a multitude of biological functions in living organisms. With the advent of methods, such as microarrays, transcriptome analysis, and proteomics, studies have been performed at the genome level to gain insight of changes in the expression profiles of genes during different stages of muscle development and of associated diseases. In the present study, a database was conceived for the straightforward retrieval of information on genes involved in skeletal muscle formation, neuromuscular diseases (NMDs), ageing, and neurodegenerative disorders (NDs). The resulting database named NeuroMuscleDB (http://yu-mbl-muscledb.com/NeuroMuscleDB) is the result of a wide literature survey, database searches, and data curation. NeuroMuscleDB contains information of genes in Homo sapiens, Mus musculus, and Bos Taurus, and their promoter sequences and specified roles at different stages of muscle development and in associated myopathies. The database contains information on ~ 1102 genes, 6030 mRNAs, and 5687 proteins, and embedded analytical tools that can be used to perform tasks related to gene sequence usage. The authors believe NeuroMuscleDB provides a platform for obtaining desired information on genes related to myogenesis and their associations with various diseases (NMDs, ageing, and NDs). NeuroMuscleDB is freely available on the web at http://yu-mbl-muscledb.com/NeuroMuscleDB and supports all major browsers. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAgeing
dc.subjectDatabase
dc.subjectGenes
dc.subjectMyogenesis
dc.subjectNeurodegenerative disorders
dc.subjectNeuromuscular dystrophies
dc.subjectSkeletal muscle
dc.subjectmessenger RNA
dc.subjectprotein
dc.subjectaging
dc.subjectArticle
dc.subjectgene
dc.subjectgene sequence
dc.subjectgenetic association
dc.subjectgenetic database
dc.subjecthuman
dc.subjectMus musculus
dc.subjectmuscle development
dc.subjectnerve degeneration
dc.subjectNeuroMuscleDB
dc.subjectneuromuscular disease
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectpromoter region
dc.subjectskeletal muscle
dc.subjecttaurine cattle
dc.subjectaging
dc.subjectanimal
dc.subjectbovine
dc.subjectgenetics
dc.subjectmouse
dc.subjectmuscle development
dc.subjectneuromuscular disease
dc.subjectnucleotide sequence
dc.subjectAging
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectCattle
dc.subjectDatabases, Genetic
dc.subjectHumans
dc.subjectMice
dc.subjectMuscle Development
dc.subjectNeuromuscular Diseases
dc.titleNeuroMuscleDB: a Database of Genes Associated with Muscle Development, Neuromuscular Diseases, Ageing, and Neurodegeneration
dc.typeArticle


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