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Protective effects of curcumin against ischemia-reperfusion injury in the liver

dc.contributor.authorBavarsad K.
dc.contributor.authorRiahi M.M.
dc.contributor.authorSaadat S.
dc.contributor.authorBarreto G.
dc.contributor.authorAtkin S.L.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:13:02Z
dc.date.available2020-09-02T22:13:02Z
dc.date.issued2019
dc.identifier10.1016/j.phrs.2018.12.014
dc.identifier.citation141, , 53-62
dc.identifier.issn10436618
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3711
dc.descriptionLiver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement. © 2018 Elsevier Ltd
dc.language.isoen
dc.publisherAcademic Press
dc.subjectCurcumin
dc.subjectIschemia-reperfusion injury
dc.subjectLiver
dc.subjectTransplantation
dc.subjectcurcumin
dc.subjectheat shock protein 70
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectcurcumin
dc.subjectprotective agent
dc.subjectbiological activity
dc.subjectclinical feature
dc.subjectdrug delivery system
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjecthuman
dc.subjectliver injury
dc.subjectliver protection
dc.subjectliver transplantation
dc.subjectnitrosative stress
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectreperfusion injury
dc.subjectReview
dc.subjectsignal transduction
dc.subjecttreatment outcome
dc.subjectanimal
dc.subjectdisease model
dc.subjectliver disease
dc.subjectreperfusion injury
dc.subjectAnimals
dc.subjectCurcumin
dc.subjectDisease Models, Animal
dc.subjectHumans
dc.subjectLiver Diseases
dc.subjectLiver Transplantation
dc.subjectProtective Agents
dc.subjectReperfusion Injury
dc.titleProtective effects of curcumin against ischemia-reperfusion injury in the liver
dc.typeReview


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