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Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System

dc.contributor.authorBavarsad K.
dc.contributor.authorBarreto G.E.
dc.contributor.authorHadjzadeh M.-A.-R.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:13:02Z
dc.date.available2020-09-02T22:13:02Z
dc.date.issued2019
dc.identifier10.1007/s12035-018-1169-7
dc.identifier.citation56, 2, 1391-1404
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3710
dc.descriptionIschemia-reperfusion injury (I/R injury) is a common feature of ischemic stroke which occurs when blood supply is restored after a period of ischemia. Although stroke is an important cause of death in the world, effective therapeutic strategies aiming at improving neurological outcomes in this disease are lacking. Various studies have suggested the involvement of different mechanisms in the pathogenesis of I/R injury in the nervous system. These mechanisms include oxidative stress, platelet adhesion and aggregation, leukocyte infiltration, complement activation, blood-brain barrier (BBB) disruption, and mitochondria-mediated mechanisms. Curcumin, an active ingredient of turmeric, can affect all these pathways and exert neuroprotective activity culminating in the amelioration of I/R injury in the nervous system. In this review, we discuss the protective effects of curcumin against I/R injury in the nervous system and highlight the studies that have linked biological functions of curcumin and I/R injury improvement. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectCentral nervous system
dc.subjectCurcumin
dc.subjectIschemia-reperfusion injury
dc.subjectNeuroprotection
dc.subjectcurcumin
dc.subjectcurcumin
dc.subjectneuroprotective agent
dc.subjectantiapoptotic activity
dc.subjectantiinflammatory activity
dc.subjectantioxidant activity
dc.subjectblood brain barrier
dc.subjectbrain injury
dc.subjectcerebrovascular accident
dc.subjectdrug mechanism
dc.subjectendoplasmic reticulum
dc.subjectendoplasmic reticulum stress
dc.subjecthuman
dc.subjectinflammation
dc.subjectmitochondrial biogenesis
dc.subjectnervous system
dc.subjectnervous system ischemia reperfusion injury
dc.subjectnervous system ischemia reperfusion injury
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectreperfusion injury
dc.subjectReview
dc.subjectspinal cord injury
dc.subjectanimal
dc.subjectbrain ischemia
dc.subjectchemically induced
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectmetabolism
dc.subjectpathology
dc.subjectreperfusion injury
dc.subjectAnimals
dc.subjectBrain Ischemia
dc.subjectCurcumin
dc.subjectDisease Models, Animal
dc.subjectHumans
dc.subjectNervous System
dc.subjectNeuroprotective Agents
dc.subjectReperfusion Injury
dc.titleProtective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System
dc.typeReview


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