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Nicotine-derived compounds as therapeutic tools against post-traumatic stress disorder

dc.contributor.authorBarreto G.E.
dc.contributor.authorYarkov A.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorAliev G.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:13:00Z
dc.date.available2020-09-02T22:13:00Z
dc.date.issued2015
dc.identifier10.2174/1381612821666150710145250
dc.identifier.citation21, 25, 3589-3595
dc.identifier.issn13816128
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3694
dc.descriptionPost-traumatic stress disorder (PTSD) is an anxiety disorder that develops after experiencing trauma. Actual therapies do not help majority of patients with PTSD. Moreover, extinguished fear memories usually reappear in the individuals when exposed to trauma cues. New drugs to reduce the impact of conditioned cues in eliciting abnormal fear responses are urgently required. Cotinine, the main metabolite of nicotine, decreased anxiety and depressive-like behavior, and enhanced fear extinction in mouse models of PTSD. Cotinine, considered a positive modulator of the α7 nicotinic acetylcholine receptor (α7nAChR), enhances fear extinction in rodents in a manner dependent on the activity of the nAChRs. Cotinine stimulates signaling pathways downstream of α7nAChR including the protein kinase B (Akt)/glycogen synthase kinase 3β (GSK3β) pathway and the extracellular signal-regulated kinases (ERKs). The stimulation of these factors promotes synaptic plasticity and the extinction of fear. In this review, we discuss the hypothesis that cotinine relieves PTSD symptoms and facilitates fear memory extinction by promoting brain plasticity through the positive modulation of presynaptic nAChRs and its effectors in the brain. © 2015 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAnxiety
dc.subjectDepressive-like behavior
dc.subjectFear extinction
dc.subjectTobacco
dc.subjectTrauma
dc.subjectcotinine
dc.subjectnicotine derivative
dc.subjectcotinine
dc.subjectnicotine
dc.subjectanxiety
dc.subjectArticle
dc.subjectdepression
dc.subjectfear
dc.subjecthuman
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectposttraumatic stress disorder
dc.subjectpriority journal
dc.subjectsmoking
dc.subjecttobacco
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectbrain
dc.subjectdrug development
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectpathophysiology
dc.subjectprocedures
dc.subjectpsychology
dc.subjectreinforcement
dc.subjectStress Disorders, Post-Traumatic
dc.subjectAnimals
dc.subjectBrain
dc.subjectCotinine
dc.subjectDrug Discovery
dc.subjectExtinction, Psychological
dc.subjectFear
dc.subjectHumans
dc.subjectNicotine
dc.subjectSmoking
dc.subjectStress Disorders, Post-Traumatic
dc.titleNicotine-derived compounds as therapeutic tools against post-traumatic stress disorder
dc.typeArticle


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