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Emerging roles for high-density lipoproteins in neurodegenerative disorders

dc.contributor.authorBahrami A.
dc.contributor.authorBarreto G.E.
dc.contributor.authorLombardi G.
dc.contributor.authorPirro M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:13:00Z
dc.date.available2020-09-02T22:13:00Z
dc.date.issued2019
dc.identifier10.1002/biof.1541
dc.identifier.citation45, 5, 725-739
dc.identifier.issn09516433
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3693
dc.descriptionLipoproteins are the complexes of different lipids and proteins, which are devoted to the transport and clearance of lipids or lipid-related molecules in the circulation. Lipoproteins have been found to play a crucial role in brain function and may influence myelination process. Among lipoproteins, high-density lipoproteins (HDLs) and their major protein component, apoA-I, are directly involved in cholesterol efflux in the brain. It has been suggested that inadequate or dysfunctional brain HDLs may contribute to cerebrovascular dysfunctions, neurodegeneration, or neurovascular instability. HDL deficiency could also promote cognitive decline through impacting on atherosclerotic risk. The focus of this review is to discuss knowledge on HDL dysregulation in neurological disorders. A better understanding on how changes in cellular HDL and apolipoprotein homeostasis affect central nervous system function may provide promising novel avenues for the treatment of specific HDL-related neurological disorders. © 2019 International Union of Biochemistry and Molecular Biology
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.subjectAlzheimer's disease
dc.subjectapolipoprotein
dc.subjectcholesterol
dc.subjectdementia
dc.subjectHDL
dc.subjectParkinson's disease
dc.subjectapolipoprotein
dc.subjecthigh density lipoprotein
dc.subjectAPOA1 protein, human
dc.subjectapolipoprotein A1
dc.subjectcholesterol
dc.subjecthigh density lipoprotein
dc.subjectAlzheimer disease
dc.subjectcentral nervous system function
dc.subjectcognitive defect
dc.subjectdegenerative disease
dc.subjectgeriatric disorder
dc.subjecthuman
dc.subjectHuntington chorea
dc.subjectlipoprotein metabolism
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectpriority journal
dc.subjectprotein homeostasis
dc.subjectReview
dc.subjectatherosclerosis
dc.subjectblood vessel
dc.subjectbrain
dc.subjectdementia
dc.subjectmemory disorder
dc.subjectmetabolism
dc.subjectpathology
dc.subjecttransport at the cellular level
dc.subjectAlzheimer Disease
dc.subjectApolipoprotein A-I
dc.subjectAtherosclerosis
dc.subjectBiological Transport
dc.subjectBlood Vessels
dc.subjectBrain
dc.subjectCholesterol
dc.subjectDementia
dc.subjectHumans
dc.subjectHuntington Disease
dc.subjectLipoproteins, HDL
dc.subjectMemory Disorders
dc.subjectParkinson Disease
dc.titleEmerging roles for high-density lipoproteins in neurodegenerative disorders
dc.typeReview


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