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Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets

dc.contributor.authorBarreto G.E.
dc.contributor.authorGómez R.M.
dc.contributor.authorBustos R.H.
dc.contributor.authorForero D.A.
dc.contributor.authorAliev G.
dc.contributor.authorTarasov V.V.
dc.contributor.authorYarla N.S.
dc.contributor.authorEcheverria V.
dc.contributor.authorGonzalez J.
dc.date.accessioned2020-09-02T22:13:00Z
dc.date.available2020-09-02T22:13:00Z
dc.date.issued2017
dc.identifier10.2174/1381612823666170406113501
dc.identifier.citation23, 28, 4189-4197
dc.identifier.issn13816128
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3691
dc.descriptionAstrocytes are important glial cells involved in the ionic regulation of the extracellular fluid in the Central Nervous System (CNS), the formation of the blood brain barrier (BBB) and the support to neurons for the maintenance of the Krebs cycle intermediaries. Even though these cells are known to be important for the brain functioning, several of their functions and their development have not been fully elucidated. In this context, identifying the algorithms used for their analysis plays a pivotal role in the development of new strategies in the study of astrocytes. The main objective of this review is to summarize the techniques that have helped to obtain transcriptomic data in astrocytes and the new algorithms that were used to perform the analysis of experimental data, elucidating new studies in which these had been used. We also highlight the current transcriptomics approaches targeting astrocytes function as a possible target for pharmacological interventions. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAstrocytes
dc.subjectBlood brain barrier
dc.subjectBrain
dc.subjectCentral nervous system
dc.subjectNeurological disorders
dc.subjectTranscriptome methods
dc.subjectaffymetrix array hybridization
dc.subjectastrocyte
dc.subjectblood brain barrier
dc.subjectbrain injury
dc.subjectcell function
dc.subjectcell hybridization
dc.subjectcentral nervous system
dc.subjectchromosome comparative genomic hybridization
dc.subjectcluster analysis
dc.subjectdata analysis
dc.subjectepilepsy
dc.subjectfluorescence in situ hybridization
dc.subjectgene expression
dc.subjectgenetic algorithm
dc.subjecthuman
dc.subjectmental disease
dc.subjectneuroprotection
dc.subjectpriority journal
dc.subjectReview
dc.subjecttranscriptomics
dc.subjectalgorithm
dc.subjectanimal
dc.subjectastrocyte
dc.subjectbrain
dc.subjectdrug design
dc.subjectgene expression profiling
dc.subjectmetabolism
dc.subjectnerve cell
dc.subjectprocedures
dc.subjecttranscriptome
dc.subjectAlgorithms
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectBlood-Brain Barrier
dc.subjectBrain
dc.subjectCentral Nervous System
dc.subjectDrug Design
dc.subjectGene Expression Profiling
dc.subjectHumans
dc.subjectNeurons
dc.subjectTranscriptome
dc.titleApproaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets
dc.typeReview


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