Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition
Autor
Barra R.
Morgan C.
Saez-Briones P.
Reyes-Parada M.
Burgos H.
Morales B.
Hernandez A.
Resumen
Studies in rats have shown that a decrease in either protein content or total dietary calories results in molecular, structural, and functional changes in the cerebral cortex and hippocampus, among other brain regions, which lead to behavioral disturbances, including learning and memory deficits. The neurobiological bases underlying those effects depend at least in part on fetal programming of the developing brain, which in turn relies on epigenetic regulation of specific genes via stable and heritable modifications of chromatin. Prenatal malnutrition also leads to epigenetic programming of obesity, and obesity on its own can lead to poor cognitive performance in humans and experimental animals, complicating understanding of the factors involved in the fetal programming of neuroplasticity deficits. This review focuses on the role of epigenetic mechanisms involved in prenatal malnutrition-induced brain disturbances, which are apparent at a later postnatal age, through either a direct effect of fetal programming on brain plasticity or an indirect effect on the brain mediated by the postnatal development of obesity. © The Author(s) 2018.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats (2020)
Burgos H.; Hernández A.; Constandil L.; Ríos M.; Flores O.; Puentes G.; Hernández K.; Morgan C.; Valladares L.; Castillo A.; ... (Elsevier B.V., 2019) -
Article
Aromatic Bromination Abolishes Deficits in Visuospatial Learning Induced by MDMA (“Ecstasy”) in Rats While Preserving the Ability to Increase LTP in the Prefrontal Cortex (2023)
Sáez-Briones, Patricio; Palma, Boris; Burgos, Héctor; Barra, Rafael; Hernández, Alejandro (MDPI, 2023-02)It has recently been demonstrated that aromatic bromination at C(2) abolishes all typical psychomotor, and some key prosocial effects of the entactogen MDMA in rats. Nevertheless, the influence of aromatic bromination on ... -
Article
Preference for high-fat diet is developed by young Swiss CD1 mice after short-term feeding and is prevented by NMDA receptor antagonists (2020)
Buttigieg A.; Flores O.; Hernández A.; Sáez-Briones P.; Burgos H.; Morgan C. (Academic Press Inc., 2014)