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4′-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation

dc.contributor.authorBaez E.
dc.contributor.authorGuio-Vega G.P.
dc.contributor.authorEcheverria V.
dc.contributor.authorSandoval-Rueda D.A.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:12:36Z
dc.date.available2020-09-02T22:12:36Z
dc.date.issued2017
dc.identifier10.1007/s12640-017-9733-x
dc.identifier.citation32, 2, 163-171
dc.identifier.issn10298428
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3667
dc.descriptionThe translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), is considered an important regulator of steroidogenesis and a potential therapeutic target in neurological disorders. Previous evidence suggests that TSPO ligands can protect cells during injury and prevent apoptosis in central nervous system (CNS) cells. However, its actions on astrocytic cells under metabolic injury are not well understood. In this study, we explored whether 4′-chlorodiazepam (Ro5–4864), a TSPO ligand, might protect astrocyte mitochondria under glucose deprivation. Our results showed that 4′-chlorodiazepam preserved cell viability and reduced nuclear fragmentation in glucose-deprived cells. These effects were accompanied by a reduced production of free radicals and maintenance of mitochondrial functions in cells treated with 4′-chlorodiazepam. Finally, our findings suggest that TSPO might be involved in reducing oxidative stress by preserving mitochondrial functions in astrocytic cells exposed to glucose withdrawal. © 2017, Springer Science+Business Media New York.
dc.language.isoen
dc.publisherSpringer New York LLC
dc.subject4′-chlorodiazepam
dc.subjectAstrocytes
dc.subjectGlucose deprivation
dc.subjectMitochondria
dc.subjectTSPO
dc.subject4' chlorodiazepam
dc.subjectfree radical
dc.subjecthydrogen peroxide
dc.subjectreactive oxygen metabolite
dc.subject4'-chlorodiazepam
dc.subjectantilipemic agent
dc.subjectbenzodiazepine derivative
dc.subjectglucose
dc.subjectArticle
dc.subjectastrocyte
dc.subjectcell death
dc.subjectcell protection
dc.subjectcell surface
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectfragmentation reaction
dc.subjectglucose deprivation
dc.subjectglucose metabolism
dc.subjectin vitro study
dc.subjectmitochondrion
dc.subjectpriority journal
dc.subjectsenescence
dc.subjectastrocyte
dc.subjectcell survival
dc.subjectdeficiency
dc.subjectDNA fragmentation
dc.subjectdose response
dc.subjectdrug effects
dc.subjecthuman
dc.subjectmetabolism
dc.subjectmitochondrial membrane potential
dc.subjectmitochondrion
dc.subjectnonparametric test
dc.subjecttransformed cell line
dc.subjectultrastructure
dc.subjectAstrocytes
dc.subjectBenzodiazepinones
dc.subjectCell Line, Transformed
dc.subjectCell Survival
dc.subjectDNA Fragmentation
dc.subjectDose-Response Relationship, Drug
dc.subjectGlucose
dc.subjectHumans
dc.subjectHypolipidemic Agents
dc.subjectMembrane Potential, Mitochondrial
dc.subjectMitochondria
dc.subjectReactive Oxygen Species
dc.subjectStatistics, Nonparametric
dc.title4′-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation
dc.typeArticle


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