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Protection by neuroglobin expression in brain pathologies

dc.contributor.authorBaez E.
dc.contributor.authorEcheverria V.
dc.contributor.authorCabezas R.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorGarcia-Segura L.M.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:12:36Z
dc.date.available2020-09-02T22:12:36Z
dc.date.issued2016
dc.identifier10.3389/fneur.2016.00146
dc.identifier.citation7, SEP, -
dc.identifier.issn16642295
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3666
dc.descriptionAstrocytes play an important role in physiological, metabolic, and structural functions, and when impaired, they can be involved in various pathologies including Alzheimer, focal ischemic stroke, and traumatic brain injury. These disorders involve an imbalance in the blood flow and nutrients such as glucose and lactate, leading to biochemical and molecular changes that cause neuronal damage, which is followed by loss of cognitive and motor functions. Previous studies have shown that astrocytes are more resilient than neurons during brain insults as a consequence of their more effective antioxidant systems, transporters, and enzymes, which made them less susceptible to excitotoxicity. In addition, astrocytes synthesize and release different protective molecules for neurons, including neuroglobin, a member of the globin family of proteins. After brain injury, neuroglobin expression is induced in astrocytes. Since neuroglobin promotes neuronal survival, its increased expression in astrocytes after brain injury may represent an endogenous neuroprotective mechanism. Here, we review the role of neuroglobin in the central nervous system, its relationship with different pathologies, and the role of different factors that regulate its expression in astrocytes. © 2016 Baez, Echeverria, Cabezas, ávila-Rodriguez, Garcia-Segura and Barreto.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAstrocytes
dc.subjectBrain injury
dc.subjectMitochondria
dc.subjectNeuroglobin
dc.subjectNeuroprotection
dc.subjectcytochrome c
dc.subjectmessenger RNA
dc.subjectneuroglobin
dc.subjectnitric oxide
dc.subjectreactive oxygen metabolite
dc.subjectAlzheimer disease
dc.subjectantioxidant activity
dc.subjectapoptosis
dc.subjectastrocyte
dc.subjectastrocytosis
dc.subjectblood brain barrier
dc.subjectbrain damage
dc.subjectbrain disease
dc.subjectbrain hypoxia
dc.subjectbrain ischemia
dc.subjecthuman
dc.subjectmitochondrion
dc.subjectnerve degeneration
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectParkinson disease
dc.subjectperception deafness
dc.subjectprotein expression
dc.subjectReview
dc.subjecttraumatic brain injury
dc.titleProtection by neuroglobin expression in brain pathologies
dc.typeReview


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