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Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression

dc.contributor.authorAvila-Rodriguez M.
dc.contributor.authorGarcia-Segura L.M.
dc.contributor.authorHidalgo-lanussa O.
dc.contributor.authorBaez E.
dc.contributor.authorGonzalez J.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:12:33Z
dc.date.available2020-09-02T22:12:33Z
dc.date.issued2016
dc.identifier10.1016/j.mce.2016.05.024
dc.identifier.citation433, , 35-46
dc.identifier.issn03037207
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3650
dc.descriptionTibolone, a synthetic steroid used for the prevention of osteoporosis and the treatment of climacteric symptoms in post-menopausal women, may exert tissue selective estrogenic actions acting on estrogen receptors (ERs). We previously showed that tibolone protects human T98G astroglial cells against glucose deprivation (GD). In this study we have explored whether the protective effect of tibolone on these cells is mediated by ERs. Experimental studies showed that both ERα and ERβ were involved in the protection by tibolone on GD cells, being ERβ preferentially involved on these actions over ERα. Tibolone increased viability of GD cells by a mechanism fully blocked by an ERβ antagonist and partially blocked by an ERα antagonist. Furthermore, ERβ inhibition prevented the effect of tibolone on nuclear fragmentation, ROS and mitochondrial membrane potential in GD cells. The protective effect of tibolone was mediated by neuroglobin. Tibolone upregulated neuroglobin in T98G cells and primary mouse astrocytes by a mechanism involving ERβ and neuroglobin silencing prevented the protective action of tibolone on GD cells. In summary, tibolone protects T98G cells by a mechanism involving ERβ and the upregulation of neuroglobin. © 2016 Elsevier Ireland Ltd.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectAstrocytes
dc.subjectERβ
dc.subjectGlucose deprivation
dc.subjectMitochondria
dc.subjectNeuroglobin
dc.subjectTibolone
dc.subjectestrogen receptor alpha
dc.subjectestrogen receptor beta
dc.subjectglucose
dc.subjectmessenger RNA
dc.subjectneuroglobin
dc.subjecttibolone
dc.subjectestrogen
dc.subjectestrogen receptor alpha
dc.subjectestrogen receptor beta
dc.subjectglobin
dc.subjectnerve protein
dc.subjectneuroglobin
dc.subjectpregnane derivative
dc.subjectprotective agent
dc.subjectreactive oxygen metabolite
dc.subjectselective estrogen receptor modulator
dc.subjecttibolone
dc.subjectanimal cell
dc.subjectArticle
dc.subjectastrocyte
dc.subjectcell protection
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectdrug mechanism
dc.subjectgene silencing
dc.subjectin vitro study
dc.subjectmale
dc.subjectmitochondrial membrane potential
dc.subjectmouse
dc.subjectNgb1 gene
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectupregulation
dc.subjectanimal
dc.subjectastrocyte
dc.subjectdrug effects
dc.subjecthuman
dc.subjectmetabolism
dc.subjecttumor cell line
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectCell Line, Tumor
dc.subjectEstrogen Receptor alpha
dc.subjectEstrogen Receptor beta
dc.subjectEstrogen Receptor Modulators
dc.subjectEstrogens
dc.subjectGlobins
dc.subjectGlucose
dc.subjectHumans
dc.subjectMembrane Potential, Mitochondrial
dc.subjectMice
dc.subjectNerve Tissue Proteins
dc.subjectNorpregnenes
dc.subjectProtective Agents
dc.subjectReactive Oxygen Species
dc.subjectUp-Regulation
dc.titleTibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression
dc.typeArticle


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