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Wnt5a Signaling in Gastric Cancer

dc.contributor.authorAstudillo P.
dc.date.accessioned2020-09-02T22:12:31Z
dc.date.available2020-09-02T22:12:31Z
dc.date.issued2020
dc.identifier10.3389/fcell.2020.00110
dc.identifier.citation8, , -
dc.identifier.issn2296634X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3643
dc.descriptionGastric cancer remains an important health challenge, accounting for a significant number of cancer-related deaths worldwide. Therefore, a deeper understanding of the molecular mechanisms involved in gastric cancer establishment and progression is highly desirable. The Wnt pathway plays a fundamental role in development, homeostasis, and disease, and abnormal Wnt signaling is commonly observed in several cancer types. Wnt5a, a ligand that activates the non-canonical branch of the Wnt pathway, can play a role as a tumor suppressor or by promoting cancer cell invasion and migration, although the molecular mechanisms explaining these roles have not been fully elucidated. Wnt5a is increased in gastric cancer samples; however, most gastric cancer cell lines seem to exhibit little expression of this ligand, thus raising the question about the source of this ligand in vivo. This review summarizes available research about Wnt5a expression and signaling in gastric cancer. In gastric cancer, Wnt5a promotes invasion and migration by modulating integrin adhesion turnover. Disheveled, a scaffolding protein with crucial roles in Wnt signaling, mediates the adhesion-related effects of Wnt5a in gastric cancer cells, and several studies provide growing support for a model whereby Disheveled-interacting proteins mediates Wnt5a signaling to modulate cytoskeleton dynamics. However, Wnt5a might induce other effects in gastric cancer cells, such as cell survival and induction of gene expression. On the other hand, the available evidence suggests that Wnt5a might be expressed by cells residing in the tumor microenvironment, where feedback mechanisms sustaining Wnt5a secretion and signaling might be established. This review analyzes the possible functions of Wnt5a in this pathological context and discusses potential links to mechanosensing and YAP/TAZ signaling. © Copyright © 2020 Astudillo.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectadhesion
dc.subjectDisheveled
dc.subjectgastric cancer
dc.subjectinvasion
dc.subjectmechanosensing
dc.subjectmetastasis
dc.subjectWnt5a
dc.subjectdishevelled protein
dc.subjectintegrin
dc.subjectTAZ protein
dc.subjecttumor protein
dc.subjectunclassified drug
dc.subjectWnt5a protein
dc.subjectyes associated protein
dc.subjectcell adhesion
dc.subjectcell invasion
dc.subjectcell migration
dc.subjectcell survival
dc.subjectcytoskeleton
dc.subjectgastric cancer cell line
dc.subjecthuman
dc.subjectmechanotransduction
dc.subjectmolecular pathology
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectprotein protein interaction
dc.subjectprotein secretion
dc.subjectReview
dc.subjectstomach cancer
dc.subjectstomach carcinogenesis
dc.subjecttumor microenvironment
dc.subjectWnt signaling
dc.titleWnt5a Signaling in Gastric Cancer
dc.typeReview


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