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Neuroprotection by curcumin: A review on brain delivery strategies

dc.contributor.authorAskarizadeh A.
dc.contributor.authorBarreto G.E.
dc.contributor.authorHenney N.C.
dc.contributor.authorMajeed M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:12:31Z
dc.date.available2020-09-02T22:12:31Z
dc.date.issued2020
dc.identifier10.1016/j.ijpharm.2020.119476
dc.identifier.citation585, , -
dc.identifier.issn03785173
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3639
dc.descriptionNeurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerative diseases and brain tumors. The blood–brain barrier (BBB) is the major obstacle for the delivery of curcumin into the brain, limiting its therapeutic potential. The development of promising approaches to facilitate curcumin transportation across the BBB may resolve some of the problems associated with drug delivery. Studies have shown nano delivery of curcumin can improve a number of outcome measures in neurodegenerative diseases. The present review highlights current and emerging strategies to facilitate curcumin permeation across the BBB for the treatment of various neurodegenerative diseases. © 2020 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectBlood-brain barrier
dc.subjectCurcumin
dc.subjectDrug delivery
dc.subjectNanotechnology
dc.subjectNeurodegeneration
dc.subjectcurcumin
dc.subjectliposome
dc.subjectmagnetic nanoparticle
dc.subjectnanocarrier
dc.subjectneuroprotective agent
dc.subjectpolymer
dc.subjectsolid lipid nanoparticle
dc.subjectblood brain barrier
dc.subjectchemical modification
dc.subjectdegenerative disease
dc.subjectdrug delivery system
dc.subjectdrug penetration
dc.subjecthuman
dc.subjectliposomal delivery
dc.subjectmicellization
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectReview
dc.titleNeuroprotection by curcumin: A review on brain delivery strategies
dc.typeReview


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