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The effects of experimental gestational hypertension on maternal blood pressure and fluid intake and pre-weanling hypothalamic neuronal activity

dc.contributor.authorArguelles J.
dc.contributor.authorPerillan C.
dc.contributor.authorBeltz T.G.
dc.contributor.authorXue B.
dc.contributor.authorBadaue-Passos D.
dc.contributor.authorJr.
dc.contributor.authorVega J.A.
dc.contributor.authorJohnson A.K.
dc.date.accessioned2020-09-02T22:12:26Z
dc.date.available2020-09-02T22:12:26Z
dc.date.issued2017
dc.identifier10.1016/j.appet.2017.04.008
dc.identifier.citation116, , 65-74
dc.identifier.issn01956663
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3609
dc.descriptionTo examine the fetal programming effects of maternal hypertension, natriophilia and hyperreninemia [experimentally induced in rats by partial inter-renal aortic ligature (PAL) prior to mating] fos immunoreactivity was studied in 6-day-old offspring of PAL and control mothers. The purposes of the present set of experiments were twofold. The first was to characterize the effects of PAL on the mother's arterial blood pressure and intake of salt (1.8% NaCl solution) and water over the course of gestation. Second, was to study the pattern of neuronal activation in key brain areas of 6-day-old offspring treated with the dipsogen isoproterenol that were from PAL and control mothers. Beta-adrenergic receptor agonist-treated pups allowed the determination whether there were neuroanatomical correlates within the neural substrates controlling thirst and the enhanced water intake evidenced by the isoproterenol treated pups of PAL mothers. Hydromineral ingestive behavior along with blood pressure and heart rate of PAL (M-PAL) and control (M-sPAL) dams throughout gestation was studied. Higher salt and water intakes along with blood pressures and heart rates were found during gestation and lactation in the M-PAL group. Maternal PAL evoked significantly increased isoproterenol-elicited Fos staining in brain regions (e.g. subfornical organ, organum vasculosum of the lamina terminalis, supraoptic nucleus, hypothalamic paraventricular nucleus and median preoptic nucleus) of 6-day-old pups, which is the age of animals shown enhanced thirst responses in PAL offspring. These results indicate that PAL is compatible with pregnancy, producing a sustained increase in blood pressure and heart rate, along with increased water and salt intake. The present study demonstrates that the neural substrates involved in cardiovascular homeostasis and fluid balance in adult rats are responsive in six-day-old rats, and can be altered by fetal programming. © 2017 Elsevier Ltd
dc.language.isoen
dc.publisherAcademic Press
dc.subjectc-Fos
dc.subjectGestation
dc.subjectHypertension
dc.subjectIsoproterenol
dc.subjectOntogeny
dc.subjectRenin-angiotensin-aldosterone system
dc.subjectThirst
dc.subjectabdominal aorta
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarterial pressure
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectexperimental hypertension
dc.subjectfemale
dc.subjectfluid intake
dc.subjectheart rate
dc.subjecthypothalamic paraventricular nucleus
dc.subjectmaternal hypertension
dc.subjectmating
dc.subjectmedial preoptic area
dc.subjectnonhuman
dc.subjectorganum vasculosum of the lamina terminalis
dc.subjectrat
dc.subjectsalt intake
dc.subjectsubfornical organ
dc.subjectsupraoptic nucleus
dc.subjecttelemetry
dc.subjectanimal
dc.subjectanimal behavior
dc.subjectblood pressure
dc.subjectbody weight gain
dc.subjectcytology
dc.subjectdisease model
dc.subjectdrinking
dc.subjectfetus development
dc.subjectgrowth, development and aging
dc.subjecthypothalamus
dc.subjectimmunohistochemistry
dc.subjectindwelling catheter
dc.subjectlactation
dc.subjectmale
dc.subjectmaternal hypertension
dc.subjectnerve cell
dc.subjectnewborn
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectSprague Dawley rat
dc.subjectthirst
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBehavior, Animal
dc.subjectBlood Pressure
dc.subjectCatheters, Indwelling
dc.subjectDisease Models, Animal
dc.subjectDrinking
dc.subjectFemale
dc.subjectFetal Development
dc.subjectHeart Rate
dc.subjectHypertension, Pregnancy-Induced
dc.subjectHypothalamus
dc.subjectImmunohistochemistry
dc.subjectLactation
dc.subjectMale
dc.subjectNeurons
dc.subjectRats, Sprague-Dawley
dc.subjectTelemetry
dc.subjectThirst
dc.subjectWeight Gain
dc.titleThe effects of experimental gestational hypertension on maternal blood pressure and fluid intake and pre-weanling hypothalamic neuronal activity
dc.typeArticle


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