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Effect of warming anesthetic on pain perception during dental injection: A split-mouth randomized clinical trial

dc.contributor.authorAravena P.C.
dc.contributor.authorBarrientos C.
dc.contributor.authorTroncoso C.
dc.contributor.authorCoronado C.
dc.contributor.authorSotelo-Hitschfeld P.
dc.date.accessioned2020-09-02T22:12:23Z
dc.date.available2020-09-02T22:12:23Z
dc.date.issued2018
dc.identifier10.2147/LRA.S147288
dc.identifier.citation11, , 9-13
dc.identifier.issn11787112
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3581
dc.descriptionBackground: The purpose of this study is to determine the effectiveness of warming anesthesia on the control of the pain produced during the administration of dental anesthesia injection and to analyze the role of Transient Receptor Potential Vanilloid-1 nociceptor channels in this effect. Patients and methods: A double-blind, split-mouth randomized clinical trial was designed. Seventy-two volunteer students (22.1±2.45 years old; 51 men) from the School of Dentistry at the Universidad Austral de Chile (Valdivia, Chile) participated. They were each administered 0.9 mL of lidocaine HCl 2% with epinephrine 1:100,000 (Alphacaine®) using two injections in the buccal vestibule at the level of the upper lateral incisor teeth. Anesthesia was administered in a hemiarch at 42°C (107.6°F) and after 1 week, anesthesia was administered by randomized sequence on the contralateral side at room temperature (21°C–69.8°F) at a standardized speed. The intensity of pain perceived during the injection was compared using a 100 mm visual analog scale (VAS; Wilcoxon test p<0.05). Results: The use of anesthesia at room temperature produced an average VAS for pain of 35.3±16.71 mm and anesthesia at 42°C produced VAS for pain of 15±14.67 mm (p<0.001). Conclusion: The use of anesthesia at 42°C significantly reduced the pain during the injection of anesthesia compared to its use at room temperature during maxillary injections. The physiological mechanism of the temperature on pain reduction could be due to a synergic action on the permeabilization of the Transient Receptor Potential Vanilloid-1 channels, allowing the passage of anesthetic inside the nociceptors. © 2018 Aravena et al.
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.subjectClinical trial
dc.subjectDental anesthesia
dc.subjectLidocaine
dc.subjectMaxillary
dc.subjectPain
dc.subjectTrigeminal nerve
dc.subjectTRP channel
dc.subjectalphacaine100
dc.subjectepinephrine
dc.subjectlidocaine
dc.subjectvanilloid receptor 1
dc.subjectadult
dc.subjectanalgesia
dc.subjectArticle
dc.subjectChile
dc.subjectclinical effectiveness
dc.subjectcontrolled study
dc.subjectdental anesthesia
dc.subjectdouble blind procedure
dc.subjectfemale
dc.subjecthuman
dc.subjectincisor
dc.subjectmale
dc.subjectnociception
dc.subjectpain intensity
dc.subjectpain receptor
dc.subjectprotein function
dc.subjectrandomized controlled trial
dc.subjectroom temperature
dc.subjectstudent
dc.subjectvestibule
dc.subjectvisual analog scale
dc.subjectwarming
dc.titleEffect of warming anesthetic on pain perception during dental injection: A split-mouth randomized clinical trial
dc.typeArticle


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