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Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: Does ejection fraction matter?

dc.contributor.authorAndrade D.C.
dc.contributor.authorArce-Alvarez A.
dc.contributor.authorToledo C.
dc.contributor.authorDíaz H.S.
dc.contributor.authorLucero C.
dc.contributor.authorQuintanilla R.A.
dc.contributor.authorSchultz H.D.
dc.contributor.authorMarcus N.J.
dc.contributor.authorAmann M.
dc.contributor.authorDel Rio R.
dc.date.accessioned2020-09-02T22:11:16Z
dc.date.available2020-09-02T22:11:16Z
dc.date.issued2018
dc.identifier10.1152/ajpheart.00407.2017
dc.identifier.citation314, 3, H464-H474
dc.identifier.issn03636135
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3569
dc.descriptionHeart failure (HF) is a global public health problem that, independent of its etiology [reduced (HFrEF) or preserved ejection fraction (HFpEF)], is characterized by functional impairments of cardiac function, chemoreflex hypersensitivity, baroreflex sensitivity (BRS) impairment, and abnormal autonomic regulation, all of which contribute to increased morbidity and mortality. Exercise training (ExT) has been identified as a nonpharmacological therapy capable of restoring normal autonomic function and improving survival in patients with HFrEF. Improvements in autonomic function after ExT are correlated with restoration of normal peripheral chemoreflex sensitivity and BRS in HFrEF. To date, few studies have addressed the effects of ExT on chemoreflex control, BRS, and cardiac autonomic control in HFpEF; however, there are some studies that have suggested that ExT has a beneficial effect on cardiac autonomic control. The beneficial effects of ExT on cardiac function and autonomic control in HF may have important implications for functional capacity in addition to their obvious importance to survival. Recent studies have suggested that the peripheral chemoreflex may also play an important role in attenuating exercise intolerance in HFrEF patients. The role of the central/peripheral chemoreflex, if any, in mediating exercise intolerance in HFpEF has not been investigated. The present review focuses on recent studies that address primary pathophysiological mechanisms of HF (HFrEF and HFpEF) and the potential avenues by which ExT exerts its beneficial effects. © 2018 American Physiological Society. All rights reserved.
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.subjectAutonomic control
dc.subjectChemoreflex drive
dc.subjectExercise training
dc.subjectHeart failure
dc.subjectkruppel like factor 2
dc.subjectaerobic exercise
dc.subjectautonomic dysfunction
dc.subjectautonomic nervous system function
dc.subjectchemoreceptor reflex
dc.subjectendurance training
dc.subjectexercise
dc.subjectexercise tolerance
dc.subjectfunctional status
dc.subjectheart arrhythmia
dc.subjectheart ejection fraction
dc.subjectheart failure
dc.subjectheart failure with preserved ejection fraction
dc.subjectheart failure with reduced ejection fraction
dc.subjectheart infarction
dc.subjectheart rate variability
dc.subjecthuman
dc.subjectmuscle blood flow
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpressoreceptor reflex
dc.subjectpriority journal
dc.subjectReview
dc.subjectsympathetic tone
dc.subjectanimal
dc.subjectautonomic nervous system
dc.subjectchemoreceptor cell
dc.subjectconvalescence
dc.subjectenergy metabolism
dc.subjectexercise tolerance
dc.subjectheart
dc.subjectheart failure
dc.subjectheart stroke volume
dc.subjectinnervation
dc.subjectkinesiotherapy
dc.subjectmetabolism
dc.subjectmuscle contraction
dc.subjectpathophysiology
dc.subjectprocedures
dc.subjectreflex
dc.subjectskeletal muscle
dc.subjecttreatment outcome
dc.subjectAnimals
dc.subjectAutonomic Nervous System
dc.subjectChemoreceptor Cells
dc.subjectEnergy Metabolism
dc.subjectExercise Therapy
dc.subjectExercise Tolerance
dc.subjectHeart
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectMuscle Contraction
dc.subjectMuscle, Skeletal
dc.subjectRecovery of Function
dc.subjectReflex
dc.subjectStroke Volume
dc.subjectTreatment Outcome
dc.titleRevisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: Does ejection fraction matter?
dc.typeReview


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