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Potent in Vitro α-Glucosidase Inhibition of Secondary Metabolites Derived from Dryopteris cycadina

dc.contributor.authorAmin S.
dc.contributor.authorUllah B.
dc.contributor.authorAli M.
dc.contributor.authorRauf A.
dc.contributor.authorKhan H.
dc.contributor.authorUriarte E.
dc.contributor.authorSobarzo-Sánchez E.
dc.date.accessioned2020-09-02T22:11:14Z
dc.date.available2020-09-02T22:11:14Z
dc.date.issued2019
dc.identifier10.3390/molecules24030427
dc.identifier.citation24, 3, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3562
dc.descriptionα-glucosidase is responsible for the hydrolysis of complex carbohydrates into simple absorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the ideal target to prevent postprandial hyperglycemia. The present study was therefore designed to analyze the effects of various compounds isolated from Dryopteris cycadina against α-glucosidase including β-Sitosterol 1, β-Sitosterol3-O-β-D-glucopyranoside 2, 3, 5, 7-trihydroxy-2-(p-tolyl) chorman-4-one 3, Quercetin-3-0-β-D-glucopyranoside (3/→0-3///)- β-D- Quercetin -3-0- β –D-galactopyranoside 4 and 5, 7, 4/-Trihydroxyflavon-3-glucopyranoid 5. The in vitro spectrophotometric method was used for the analysis of test compounds against possible inhibition. Similarly, molecular docking studies were performed using the MOE software. These compounds showed concentration-dependent inhibition on α-glucosidase, and compounds 1 (IC50: 143 ± 0.47 µM), 3 (IC50:133 ± 6.90 µM) and 5 (IC50: 146 ± 1.93 µM) were more potent than the standard drug, acarbose (IC50: 290 ± 0.54 µM). Computational studies of these compounds strongly supported the in vitro studies and showed strong binding receptor sensitivity. In short, the secondary metabolites isolated from D. cycadina demonstrated potent α-glucosidase inhibition that were supported by molecular docking with a high docking score. © 2019 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectDryopteris cycadina
dc.subjectIsolated compounds
dc.subjectMolecular docking
dc.subjectα-glucosidase inhibition
dc.subjectacarbose
dc.subjectalpha glucosidase
dc.subjectgalactose
dc.subjectgamma-sitosterol
dc.subjectglycosidase inhibitor
dc.subjectphytochemical
dc.subjectprotein binding
dc.subjectquercetin
dc.subjectsitosterol derivative
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectDryopteris
dc.subjectisolation and purification
dc.subjectmetabolism
dc.subjectmolecular docking
dc.subjectsecondary metabolism
dc.subjectstructure activity relation
dc.subjectAcarbose
dc.subjectalpha-Glucosidases
dc.subjectDryopteris
dc.subjectGalactose
dc.subjectGlycoside Hydrolase Inhibitors
dc.subjectMolecular Docking Simulation
dc.subjectMolecular Structure
dc.subjectPhytochemicals
dc.subjectProtein Binding
dc.subjectQuercetin
dc.subjectSecondary Metabolism
dc.subjectSitosterols
dc.subjectStructure-Activity Relationship
dc.titlePotent in Vitro α-Glucosidase Inhibition of Secondary Metabolites Derived from Dryopteris cycadina
dc.typeArticle


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