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Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice

dc.contributor.authorAlvarez-Ricartes N.
dc.contributor.authorOliveros-Matus P.
dc.contributor.authorMendoza C.
dc.contributor.authorPerez-Urrutia N.
dc.contributor.authorEcheverria F.
dc.contributor.authorIarkov A.
dc.contributor.authorBarreto G.E.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:11:12Z
dc.date.available2020-09-02T22:11:12Z
dc.date.issued2018
dc.identifier10.1007/s12035-018-0916-0
dc.identifier.citation55, 10, 7949-7960
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3552
dc.descriptionFailure in fear extinction is one of the more troublesome characteristics of posttraumatic stress disorder (PTSD). Cotinine facilitates fear memory extinction and reduces depressive-like behavior when administered 24 h after fear conditioning in mice. In this study, it was investigated the behavioral and molecular effects of cotinine, and other antidepressant preparations infused intranasally. Intranasal (IN) cotinine, IN krill oil, IN cotinine plus krill oil, and oral sertraline were evaluated on depressive-like behavior and fear retention and extinction after fear conditioning in C57BL/6 mice. Since calcineurin A has been involved in facilitating fear extinction in rodents, we also investigated changes of calcineurin in the hippocampus, a region key on contextual fear extinction. Short-term treatment with cotinine formulations was superior to krill oil and oral sertraline in reducing depressive-like behavior and fear consolidation and enhancing contextual fear memory extinction in mice. IN krill oil slowed the extinction of fear. IN cotinine preparations increased the levels of calcineurin A in the hippocampus of conditioned mice. In the light of the results, the future investigation of the use of IN cotinine preparations for the extinction of contextual fear memory and treatment of treatment-resistant depression (TRD) in PTSD is discussed. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectCotinine
dc.subjectDepression
dc.subjectFear extinction
dc.subjectKrill oil
dc.subjectPosttraumatic stress disorder
dc.subjectcalcineurin
dc.subjectcalcineurin A
dc.subjectcotinine
dc.subjectfish oil
dc.subjectkrill oil
dc.subjectsertraline
dc.subjectunclassified drug
dc.subjectcalcineurin
dc.subjectcotinine
dc.subjectoil
dc.subjectsertraline
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectfear
dc.subjectfear conditioning test
dc.subjectfear extinction
dc.subjecthippocampus
dc.subjectmemory consolidation
dc.subjectmouse
dc.subjectnonhuman
dc.subjectreinforcement
dc.subjectanimal
dc.subjectanimal behavior
dc.subjectbiological model
dc.subjectC57BL mouse
dc.subjectchemistry
dc.subjectconditioning
dc.subjectdepression
dc.subjectdrug effect
dc.subjectfear
dc.subjecthippocampus
dc.subjectintranasal drug administration
dc.subjectkrill
dc.subjectmetabolism
dc.subjectpsychology
dc.subjectAdministration, Intranasal
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectCalcineurin
dc.subjectConditioning (Psychology)
dc.subjectCotinine
dc.subjectDepression
dc.subjectEuphausiacea
dc.subjectExtinction, Psychological
dc.subjectFear
dc.subjectHippocampus
dc.subjectMice, Inbred C57BL
dc.subjectModels, Biological
dc.subjectOils
dc.subjectSertraline
dc.titleIntranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice
dc.typeArticle


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