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Osteoimmunology of oral and maxillofacial diseases: Translational applications based on biological mechanisms

dc.contributor.authorAlvarez C.
dc.contributor.authorMonasterio G.
dc.contributor.authorCavalla F.
dc.contributor.authorCórdova L.A.
dc.contributor.authorHernández M.
dc.contributor.authorHeymann D.
dc.contributor.authorGarlet G.P.
dc.contributor.authorSorsa T.
dc.contributor.authorPärnänen P.
dc.contributor.authorLee H.-M.
dc.contributor.authorGolub L.M.
dc.contributor.authorVernal R.
dc.contributor.authorKantarci A.
dc.date.accessioned2020-09-02T22:11:10Z
dc.date.available2020-09-02T22:11:10Z
dc.date.issued2019
dc.identifier10.3389/fimmu.2019.01664
dc.identifier.citation10, JULY, -
dc.identifier.issn16643224
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3545
dc.descriptionThe maxillofacial skeleton is highly dynamic and requires a constant equilibrium between the bone resorption and bone formation. The field of osteoimmunology explores the interactions between bone metabolism and the immune response, providing a context to study the complex cellular and molecular networks involved in oro-maxillofacial osteolytic diseases. In this review, we present a framework for understanding the potential mechanisms underlying the immuno-pathobiology in etiologically-diverse diseases that affect the oral and maxillofacial region and share bone destruction as their common clinical outcome. These otherwise different pathologies share similar inflammatory pathways mediated by central cellular players, such as macrophages, T and B cells, that promote the differentiation and activation of osteoclasts, ineffective or insufficient bone apposition by osteoblasts, and the continuous production of osteoclastogenic signals by immune and local stromal cells. We also present the potential translational applications of this knowledge based on the biological mechanisms involved in the inflammation-induced bone destruction. Such applications can be the development of immune-based therapies that promote bone healing/regeneration, the identification of host-derived inflammatory/collagenolytic biomarkers as diagnostics tools, the assessment of links between oral and systemic diseases; and the characterization of genetic polymorphisms in immune or bone-related genes that will help diagnosis of susceptible individuals. © 2019 Alvarez, Monasterio, Cavalla, Córdova, HeRNÁndez, Heymann, Garlet, Sorsa, PäRNÄnen, Lee, Golub, VeRNAl and Kantarci.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectBiomarkers
dc.subjectMaxillofacial
dc.subjectOral
dc.subjectOsteoimmunology
dc.subjectPeriodontal disease
dc.subjectbasic leucine zipper transcription factor
dc.subjectC reactive protein
dc.subjectcathepsin
dc.subjectCXCL1 chemokine
dc.subjectdextro tyrosylisoleucylcysteinylvalyl 1 methyltryptophylglutaminylaspartyltryptophyl n methylglycylalanylhistidylarginylcysteinyl n methylisoleucinamide 3,13 cyclic sulfide
dc.subjectdoxycycline
dc.subjectdoxycycline hyclate
dc.subjectgelatinase B
dc.subjectheat shock protein 27
dc.subjectinterferon regulatory factor 4
dc.subjectinterleukin 1
dc.subjectinterleukin 12
dc.subjectinterleukin 17
dc.subjectinterleukin 2
dc.subjectinterleukin 22
dc.subjectinterleukin 23
dc.subjectinterleukin 6
dc.subjectinterleukin 8
dc.subjectmacrophage inflammatory protein 3alpha
dc.subjectneutrophil collagenase
dc.subjectNotch2 receptor
dc.subjectosteoclast differentiation factor
dc.subjectRANTES
dc.subjectreactive oxygen metabolite
dc.subjectrosiglitazone
dc.subjectserine proteinase inhibitor
dc.subjectstromal cell derived factor 1
dc.subjecttamibarotene
dc.subjecttoll like receptor 4
dc.subjecttumor necrosis factor
dc.subjectunindexed drug
dc.subjectbone atrophy
dc.subjectbone destruction
dc.subjectbone metabolism
dc.subjectbone regeneration
dc.subjectcell activation
dc.subjectcell differentiation
dc.subjectchondrosarcoma
dc.subjectclinical assessment
dc.subjectclinical outcome
dc.subjectEwing sarcoma
dc.subjectgenetic polymorphism
dc.subjectgingivitis
dc.subjecthuman
dc.subjectimmune response
dc.subjectimmunology
dc.subjectimmunomodulation
dc.subjectimmunopathology
dc.subjectimmunoregulation
dc.subjectmaxillofacial disorder
dc.subjectmouth disease
dc.subjectnonhuman
dc.subjectossification
dc.subjectosteoblast
dc.subjectosteoclast
dc.subjectosteoclastogenesis
dc.subjectosteosarcoma
dc.subjectperiodontal disease
dc.subjectperiodontitis
dc.subjectReview
dc.subjecttooth periapical disease
dc.subjecttranslational research
dc.titleOsteoimmunology of oral and maxillofacial diseases: Translational applications based on biological mechanisms
dc.typeReview


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