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Interactions in blends of dendronized polymeric nanocomposites with some common drugs

dc.contributor.authorAlvarado N.
dc.contributor.authorFuentes I.
dc.contributor.authorAlegría L.
dc.contributor.authorSandoval C.
dc.contributor.authorKortabería G.
dc.contributor.authorEceiza A.
dc.contributor.authorGargallo L.
dc.contributor.authorLeiva A.
dc.contributor.authorRadic D.
dc.date.accessioned2020-09-02T22:11:10Z
dc.date.available2020-09-02T22:11:10Z
dc.date.issued2015
dc.identifier10.1002/app.42450
dc.identifier.citation132, 34, -
dc.identifier.issn00218995
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3543
dc.descriptionPoly(diethylaminoethyl methacrylamide) (PEAM), a dendronized polymer, was synthesized according to classical procedures. Monomers and polymers were characterized by spectroscopic measurements. The results obtained were in agreement with the expected chemical structure. The phase behavior of blends of PEAM with diclofenac (DCF), ibuprofen (IBU), and paracetamol (PCM) were studied by different experimental techniques. FT-IR, UV-Vis, DSC, and TGA measurements suggested important interactions between the blended components. Thermogravimetric analysis (TGA) indicated the temperature at which the dendronized polymer released a small molecule. AFM measurements and molecular dynamics (MD) simulations were used to better understand the nature of the interactions and to estimate the distance between the components of the blends to explain the interaction involved. © 2015 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.subjectblends
dc.subjectcompatibilization
dc.subjectdendrimers
dc.subjecthyperbranched polymers and macrocycles
dc.subjectstructure-property relations
dc.subjecttheory and modeling
dc.subjectBlending
dc.subjectCompatibilizers
dc.subjectCopolymers
dc.subjectDendrimers
dc.subjectDrug products
dc.subjectMolecular dynamics
dc.subjectDendronized polymers
dc.subjectExperimental techniques
dc.subjectMacrocycles
dc.subjectMolecular dynamics simulations
dc.subjectPolymeric nanocomposites
dc.subjectSpectroscopic measurements
dc.subjectStructure property relation
dc.subjectTheory and modeling
dc.subjectThermogravimetric analysis
dc.titleInteractions in blends of dendronized polymeric nanocomposites with some common drugs
dc.typeArticle


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