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Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4

dc.contributor.authorAlonso-González P.
dc.contributor.authorCabo R.
dc.contributor.authorSan José I.
dc.contributor.authorGago A.
dc.contributor.authorSuazo I.C.
dc.contributor.authorGarcía-Suárez O.
dc.contributor.authorCobo J.
dc.contributor.authorVega J.A.
dc.date.accessioned2020-09-02T22:11:09Z
dc.date.available2020-09-02T22:11:09Z
dc.date.issued2017
dc.identifier10.1002/ar.23522
dc.identifier.citation300, 6, 1022-1031
dc.identifier.issn19328486
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3538
dc.descriptionIon channels are at the basis of the sensory processes including mechanosensing. Some members of the transient receptor potential (TRP) ion channel superfamily have been proposed as mechanosensors, but their putative role in mechanotransduction is controversial. Among them there are TRP canonical 6 (TRPC6) and TRP vanilloid 4 (TRPV4) ion channels, which are known to cooperate in mechanical hyperalgesia. Here, we investigated the occurrence, distribution, and possible colocalization of TRPC6 and TRPV4 in human digital Meissner sensory corpuscles using immunohistochemistry and double immunofluorescence (associate with markers for specific corpuscular constituents). TRPC6 immunoreactivity was restricted to the axon of Meissner corpuscles, whereas TRPV4 was detected in the axon but also in the lamellar cells. Moreover, axonal colocalization of TRPV4 and TRPC6 was found in the digital Meissner corpuscles. Present results demonstrate for the first time the occurrence and colocalization of two ion channels candidates to mechanosensors in human cutaneous mechanoreceptors. The functional significance of these ion channels in that place remains to be clarified, but should be related to different properties of mechanosensitivity. Anat Rec, 300:1022–1031, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.subjecthuman
dc.subjectmechanosensing
dc.subjectMeissner corpuscles
dc.subjecttransient receptor potential ion channels
dc.subjecttransient receptor potential channel 6
dc.subjectvanilloid receptor 4
dc.subjecttransient receptor potential channel 6
dc.subjectTRPC6 protein, human
dc.subjectTRPV4 protein, human
dc.subjectvanilloid receptor
dc.subjectadult
dc.subjectArticle
dc.subjectaxon
dc.subjectcontrolled study
dc.subjectdigital meissner corpuscle
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunofluorescence
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmale
dc.subjectmechanoreceptor
dc.subjectmechanotransduction
dc.subjectpriority journal
dc.subjectprotein localization
dc.subjectfinger
dc.subjectinnervation
dc.subjectmechanoreceptor
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectyoung adult
dc.subjectAdult
dc.subjectFemale
dc.subjectFingers
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMechanoreceptors
dc.subjectMiddle Aged
dc.subjectTRPC6 Cation Channel
dc.subjectTRPV Cation Channels
dc.subjectYoung Adult
dc.titleHuman Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4
dc.typeArticle


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