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The role of efferocytosis in autoimmune diseases

dc.contributor.authorAbdolmaleki F.
dc.contributor.authorFarahani N.
dc.contributor.authorHayat S.M.G.
dc.contributor.authorPirro M.
dc.contributor.authorBianconi V.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:11:08Z
dc.date.available2020-09-02T22:11:08Z
dc.date.issued2018
dc.identifier10.3389/fimmu.2018.01645
dc.identifier.citation9, JUL, -
dc.identifier.issn16643224
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3537
dc.descriptionApoptosis happens continuously for millions of cells along with the active removal of apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, i.e., the process of dead cell clearance, is orchestrated through cell exposure of a set of "find me," "eat me, "and "tolerate me" signals facilitating the engulfment of dying cells through phagocytosis by macrophages and dendritic cells. The clearance of dead cells via phagocytes is of utmost importance to maintain the immune system tolerance to self-antigens. Accordingly, this biological activity prevents the release of autoantigens by dead cells, thus potentially suppressing the undesirable autoreactivity of immune cells and the appearance of inflammatory autoimmune disorders as systemic lupus erythematous and rheumatoid arthritis. In the present study, the apoptosis pathways and their immune regulation were reviewed. Moreover, efferocytosis process and its impairment in association with some autoimmune diseases were discussed. © 2018 Abdolmaleki, Farahani, Gheibi Hayat, Pirro, Bianconi, Barreto and Sahebkar.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectApoptosis
dc.subjectAutoimmune disease
dc.subjectEfferocytosis
dc.subjectPhagocytosis
dc.subjectSystemic lupus erythematous
dc.subjectapoptotic protease activating factor 1
dc.subjectautoantigen
dc.subjectautophagy related protein
dc.subjectcalreticulin
dc.subjectcaspase
dc.subjectcaspase recruitment domain protein 15
dc.subjectCD14 antigen
dc.subjectfractalkine
dc.subjecthepatitis A virus cellular receptor 2
dc.subjectinterleukin 10
dc.subjectkidney injury molecule 1
dc.subjectlysophosphatidylcholine
dc.subjectprotein bcl 2
dc.subjectpurinergic P2X receptor
dc.subjectpurinergic P2X7 receptor
dc.subjectpurinergic P2Y receptor
dc.subjectRho kinase
dc.subjectsphingosine 1 phosphate
dc.subjecttoll like receptor 4
dc.subjecttumor necrosis factor receptor
dc.subjecttumor necrosis factor receptor associated death domain protein
dc.subjectanemia
dc.subjectapoptosis
dc.subjectautoimmune disease
dc.subjectautoimmune lymphoproliferative syndrome
dc.subjectCrohn disease
dc.subjectdendritic cell
dc.subjectefferocytosis
dc.subjectimmunological tolerance
dc.subjectimmunoregulation
dc.subjectinsulin dependent diabetes mellitus
dc.subjectmacrophage
dc.subjectmitochondrial permeability
dc.subjectmultiple sclerosis
dc.subjectnonhuman
dc.subjectpolyarthritis
dc.subjectprotein expression
dc.subjectreal time polymerase chain reaction
dc.subjectReview
dc.subjectrheumatoid arthritis
dc.subjectsystemic lupus erythematosus
dc.subjecttumor microenvironment
dc.subjectTUNEL assay
dc.subjectulcerative colitis
dc.titleThe role of efferocytosis in autoimmune diseases
dc.typeReview


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