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Can vitamin D status be assessed by serum 25OHD in children?

dc.contributor.authorAlonso M.A.
dc.contributor.authorPallavicini Z.F.
dc.contributor.authorRodríguez J.
dc.contributor.authorAvello N.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorSantos F.
dc.date.accessioned2020-09-02T22:11:08Z
dc.date.available2020-09-02T22:11:08Z
dc.date.issued2015
dc.identifier10.1007/s00467-014-2927-z
dc.identifier.citation30, 2, 327-332
dc.identifier.issn0931041X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3536
dc.descriptionBackground To examine the relationship of serum 25-hydroxyvitamin D (25OHD) concentrations with serum parathyroid hormone (PTH) levels, body mass index (BMI), and environmental factors in a population of Caucasian children living at latitude 43°N. Methods Cross-sectional study on 288 children aged 1 month to 13 years who presented to a pediatric emergency unit during a 21-month period. Results Mean (SD) serum 25OHD concentrations were 40.6 (17.6), 30.9 (12.0), and 26.4 (9.9) ng/ml (1 ng/ml=2.5 nmol/ l), in children aged 0–1, 2–5, and≥6 years, respectively. Serum PTH levels were 26.6 (13.6), 24.3 (11.9), and 32.7 (12.1) pg/ml in the same groups. Infants had 25OHD concentrations significantly higher. PTH levels were significantly higher in children aged≥6 years. There was no significant correlation between serum 25OHD and PTH concentrations. Totals of 15.6% and 2.1% of children had 25OHD values less than 20 and 10 ng/ml, respectively, but none had elevated serum PTH or clinical manifestations related with vitamin D deficiency. Age (inverse correlation) and season (higher values in summer), but not BMI, sex, and time spent outdoors, influenced serum 25OHD concentrations. Conclusions Our results raise doubt on the assumption of only a serum 25OHD threshold as indicative of vitamin D deficiency in children. © IPNA 2014
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject25OHD
dc.subjectChildren
dc.subjectCorrelation
dc.subjectDeficiency
dc.subjectPTH
dc.subjectThreshold
dc.subject25 hydroxyvitamin D
dc.subjectparathyroid hormone
dc.subject25-hydroxyvitamin D
dc.subjectparathyroid hormone
dc.subjectvitamin D
dc.subjectadolescent
dc.subjectage
dc.subjectArticle
dc.subjectbody mass
dc.subjectCaucasian
dc.subjectchild
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectenvironmental factor
dc.subjectfemale
dc.subjecthuman
dc.subjectinfant
dc.subjectlatitude
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectparathyroid hormone blood level
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectseasonal variation
dc.subjectspring
dc.subjectsummer
dc.subjectvitamin blood level
dc.subjectanalogs and derivatives
dc.subjectblood
dc.subjectluminescence
dc.subjectpreschool child
dc.subjectSpain
dc.subjectvitamin D deficiency
dc.subjectAdolescent
dc.subjectBody Mass Index
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectLuminescent Measurements
dc.subjectMale
dc.subjectParathyroid Hormone
dc.subjectSpain
dc.subjectVitamin D
dc.subjectVitamin D Deficiency
dc.titleCan vitamin D status be assessed by serum 25OHD in children?
dc.typeArticle


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