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Nanoparticles as alternative strategies for drug delivery to the Alzheimer brain: Electron microscopy ultrastructural analysis

dc.contributor.authorAliev G.
dc.contributor.authorDaza J.
dc.contributor.authorHerrera A.S.
dc.contributor.authorEsparza M.D.C.A.
dc.contributor.authorMorales L.
dc.contributor.authorEcheverria V.
dc.contributor.authorBachurin S.O.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:11:06Z
dc.date.available2020-09-02T22:11:06Z
dc.date.issued2015
dc.identifier10.2174/1871527314666150821102631
dc.identifier.citation14, 9, 1235-1242
dc.identifier.issn18715273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3520
dc.descriptionOne of the biggest problems and challenges for the development of new drugs and treatment strategies against Alzheimer Disease (AD) is the crossing of target drugs into the blood brain barrier. The use of nanoparticles in drug delivery therapy holds much promise in targeting remote tissues, and as a result many studies have attempted to study the ultrastructural localization of nanoparticles in various tissues. However, there are currently no in vivo studies demonstrating the ultrastructural distribution of nanoparticles in the brain. The aim of this study was to address how intraperitoneal injection of silver nanoparticles in the brain leads to leaking on the inter-endothelial contact and luminal plasma membrane, thus elucidating the possibility of penetrating into the most affected areas in the Alzheimer brain (vascular endothelium, perivascular, neuronal and glial cells). Our results show that the silver nanoparticles reached the brain and were found in hippocampal areas, indicating that they can be conjugated and used to deliver the drugs into the cell cytoplasm of the damaged brain cells. The present study can be useful for the development of novel drug delivering therapy and useful in understanding the delivery, distribution and effects of silver nanoparticles in AD brain tissue at cellular and subcellular level. © 2015 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAlzheimer disease
dc.subjectBlood-brain-barrier
dc.subjectDementia
dc.subjectDrug delivery
dc.subjectElectron microscopy
dc.subjectSilver nanoparticles
dc.subjectVascular endothelium
dc.subjectsilver nanoparticle
dc.subjectmetal nanoparticle
dc.subjectneuroprotective agent
dc.subjectsilver derivative
dc.subjectadult
dc.subjectAlzheimer disease
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcell structure
dc.subjectcontrolled study
dc.subjectdrug delivery system
dc.subjectextracellular matrix
dc.subjectfemale
dc.subjecthippocampal CA1 region
dc.subjectmale
dc.subjectmicrovasculature
dc.subjectnonhuman
dc.subjectrat
dc.subjecttransmission electron microscopy
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectanimal model
dc.subjectblood brain barrier
dc.subjectbrain
dc.subjectdrug delivery system
dc.subjectdrug effects
dc.subjectelectron microscopy
dc.subjectintraperitoneal drug administration
dc.subjectnerve cell
dc.subjectpathology
dc.subjectprocedures
dc.subjectultrastructure
dc.subjectvascularization
dc.subjectWistar rat
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectBlood-Brain Barrier
dc.subjectBrain
dc.subjectDrug Delivery Systems
dc.subjectFemale
dc.subjectInjections, Intraperitoneal
dc.subjectMale
dc.subjectMetal Nanoparticles
dc.subjectMicroscopy, Electron
dc.subjectMicrovessels
dc.subjectModels, Animal
dc.subjectNeurons
dc.subjectNeuroprotective Agents
dc.subjectRats, Wistar
dc.subjectSilver Compounds
dc.titleNanoparticles as alternative strategies for drug delivery to the Alzheimer brain: Electron microscopy ultrastructural analysis
dc.typeArticle


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