Mostrar el registro sencillo del ítem

Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders

dc.contributor.authorAlexiou A.
dc.contributor.authorSoursou G.
dc.contributor.authorChatzichronis S.
dc.contributor.authorGasparatos E.
dc.contributor.authorKamal M.A.
dc.contributor.authorYarla N.S.
dc.contributor.authorPerveen A.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAshraf G.M.
dc.date.accessioned2020-09-02T22:11:05Z
dc.date.available2020-09-02T22:11:05Z
dc.date.issued2019
dc.identifier10.1007/s12035-018-1397-x
dc.identifier.citation56, 6, 4530-4538
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3516
dc.descriptionData obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer’s disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAlzheimer’s disease
dc.subjectMitochondria
dc.subjectMitochondrial dynamics
dc.subjectNeurodegenerative diseases
dc.subjectOxidative stress
dc.subjectParkinson’s disease
dc.subjectguanosine triphosphatase
dc.subjectguanosine triphosphatase
dc.subjectAlzheimer disease
dc.subjectcell death
dc.subjectcell population
dc.subjectcentral nervous system disease
dc.subjectclinical feature
dc.subjectcomplex formation
dc.subjectdisease association
dc.subjectdisorders of mitochondrial functions
dc.subjecthuman
dc.subjectmitochondrial dynamics
dc.subjectmitophagy
dc.subjectnerve conduction
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpathogenesis
dc.subjectReview
dc.subjectrisk factor
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectbiological model
dc.subjectcentral nervous system disease
dc.subjectenzymology
dc.subjectmetabolism
dc.subjectmitochondrion
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectCentral Nervous System Diseases
dc.subjectGTP Phosphohydrolases
dc.subjectHumans
dc.subjectMitochondria
dc.subjectMitochondrial Dynamics
dc.subjectModels, Biological
dc.titleRole of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85055553727.pdf
Tamaño:
3.221Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem