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Stability of antibacterial silver carboxylate complexes against staphylococcus epidermidis and their cytotoxic effects

dc.contributor.authorAldabaldetrecu M.
dc.contributor.authorTamayo L.
dc.contributor.authorAlarcon R.
dc.contributor.authorWalter M.
dc.contributor.authorSalas-Huenuleo E.
dc.contributor.authorKogan M.J.
dc.contributor.authorGuerrero J.
dc.contributor.authorPaez M.
dc.contributor.authorAzócar M.I.
dc.date.accessioned2020-09-02T22:11:04Z
dc.date.available2020-09-02T22:11:04Z
dc.date.issued2018
dc.identifier10.3390/molecules23071629
dc.identifier.citation23, 7, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3511
dc.descriptionThe antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications. © 2018 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectHuman ovarian cancer cell (A2780)
dc.subjectMurine fibroblast
dc.subjectSilver antibacterial
dc.subjectStaphylococcus epidermidis
dc.subject5-chlorosalicylic acid
dc.subjectaminosalicylic acid derivative
dc.subjectantiinfective agent
dc.subjectcoordination compound
dc.subjectsalicylic acid derivative
dc.subjectsilver
dc.subjectanimal
dc.subjectcell line
dc.subjectchemistry
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectdrug stability
dc.subjecthuman
dc.subjectmicrobial sensitivity test
dc.subjectmouse
dc.subjectscanning electron microscopy
dc.subjectStaphylococcus epidermidis
dc.subjectsynthesis
dc.subjecttransmission electron microscopy
dc.subjectAminosalicylic Acids
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectCell Line
dc.subjectCoordination Complexes
dc.subjectDrug Stability
dc.subjectHumans
dc.subjectMice
dc.subjectMicrobial Sensitivity Tests
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMicroscopy, Electron, Transmission
dc.subjectSalicylates
dc.subjectSilver
dc.subjectStaphylococcus epidermidis
dc.titleStability of antibacterial silver carboxylate complexes against staphylococcus epidermidis and their cytotoxic effects
dc.typeArticle


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