Mostrar el registro sencillo del ítem

Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?

dc.contributor.authorAlcaraz-Iborra M.
dc.contributor.authorCubero I.
dc.date.accessioned2020-09-02T22:11:04Z
dc.date.available2020-09-02T22:11:04Z
dc.date.issued2015
dc.identifier10.1016/j.pbb.2015.04.012
dc.identifier.citation134, , 31-34
dc.identifier.issn00913057
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3508
dc.descriptionOrexins (OX) are neuropeptides synthesized in the lateral hypothalamic region which play a fundamental role in a wide range of physiological and psychological functions including arousal, stress, motivation or eating behaviors. This paper reviews under the addiction cycle framework (Koob, 2010), the role of the OX system as a key modulator in compulsivity-driven consumption of rewarding stimulus including ethanol, palatable food and drugs and their role in impulsivity and binge-like consumption in non dependent organisms as well. We propose here that drug/food binge-like consumption in vulnerable organisms increases OX activity which, in turn, elicits enhanced impulsivity and further impulsivity-driven binge consumption in a positive loop that would promote compulsive-driven binge-consumption and the transition to drug/food disorders over time. © 2015 Elsevier Inc.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectBinge consumption
dc.subjectCompulsivity
dc.subjectImpulsivity
dc.subjectOrexins
dc.subjectThe addiction cycle
dc.subjectalcohol
dc.subjectorexin 1 receptor
dc.subjectorexin
dc.subjectaddiction cycle
dc.subjectalcohol consumption
dc.subjectbinge eating disorder
dc.subjectcataplexy
dc.subjectcerebrospinal fluid
dc.subjectcompulsion
dc.subjectconceptual framework
dc.subjectdiet restriction
dc.subjectdorsomedial hypothalamic nucleus
dc.subjectdrug dependence
dc.subjectfood intake
dc.subjecthormone release
dc.subjecthuman
dc.subjectimpulsiveness
dc.subjectlateral hypothalamus
dc.subjectneurobiology
dc.subjectneuroendocrine system
dc.subjectneurotransmission
dc.subjectnonhuman
dc.subjectplace preference
dc.subjectpriority journal
dc.subjectReview
dc.subjectreward
dc.subjectsignal transduction
dc.subjectvulnerable population
dc.subjectanimal
dc.subjectdrug dependence
dc.subjectphysiology
dc.subjectpsychology
dc.subjectAnimals
dc.subjectHumans
dc.subjectOrexins
dc.subjectReward
dc.subjectSubstance-Related Disorders
dc.titleDo Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84929657408.pdf
Tamaño:
3.030Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem