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Binge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL/6J mice: Pharmacological and molecular evidence of orexin involvement

dc.contributor.authorAlcaraz-Iborra M.
dc.contributor.authorCarvajal F.
dc.contributor.authorLerma-Cabrera J.M.
dc.contributor.authorValor L.M.
dc.contributor.authorCubero I.
dc.date.accessioned2020-09-02T22:11:04Z
dc.date.available2020-09-02T22:11:04Z
dc.date.issued2014
dc.identifier10.1016/j.bbr.2014.06.049
dc.identifier.citation272, , 93-99
dc.identifier.issn01664328
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3507
dc.descriptionThe orexin (OX) system has been implicated in food-reinforced behavior, food-seeking and food overconsumption. Recent evidence suggests that OX signaling might influence consumption of palatable foods with high reinforcing value depending upon the caloric status of the animal. The present study evaluates from a pharmacological and a molecular approach the contribution of OX to excessive binge-like consumption of highly preferred palatable substances (sucrose and saccharin) in ad libitum-fed C57BL/6J mice. The main findings of this study are: (1) intraperitoneal (ip) injection of SB-334867 (10, 20 or 30. mg/kg), a selective OXR1 antagonist, significantly decreased binge-like consumption of sucrose (10%, w/v) and saccharin (0.15%, w/v) during the test day in a Drinking in the Dark procedure in ad libitum-fed animals, without evidence of any significant alteration of locomotor activity. (2) Four repetitive, 2-h daily episodes of sucrose and saccharin (but not water) binge-like drinking significantly dampened OX mRNA expression in the LH. Present findings show for the first time a role for OXR1 signaling in binge-like consumption of palatable substances in animals under no caloric needs. Targeting OXR1 could represent a novel pharmacological approach to treat binge-eating episodes. © 2014 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier
dc.subjectBinge-like consumption
dc.subjectDrinking in the Dark (DID)
dc.subjectOrexins
dc.subjectPalatable substances
dc.subject1 (2 methyl 6 benzoxazolyl) 3 (1,5 naphthyridin 4 yl)urea
dc.subjectmessenger RNA
dc.subjectorexin
dc.subjectorexin 1 receptor
dc.subjectsaccharin
dc.subjectsucrose
dc.subject1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea
dc.subjectagents interacting with transmitter, hormone or drug receptors
dc.subjectbenzoxazole derivative
dc.subjectdrinking water
dc.subjectmessenger RNA
dc.subjectmitochondrial protein
dc.subjectneuropeptide
dc.subjectnuclear protein
dc.subjectorexins
dc.subjectOxr1 protein, mouse
dc.subjectsaccharin
dc.subjectsignal peptide
dc.subjectsugar intake
dc.subjecturea
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbinge eating disorder
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrinking behavior
dc.subjectdrug dose comparison
dc.subjectdrug effect
dc.subjectgene expression
dc.subjectlateral hypothalamus
dc.subjectlocomotion
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsignal transduction
dc.subjectadministration and dosage
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectantagonists and inhibitors
dc.subjectbulimia
dc.subjectC57BL mouse
dc.subjectcaloric intake
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectmotor activity
dc.subjectphysiology
dc.subjectsugar intake
dc.subjectAnimals
dc.subjectBenzoxazoles
dc.subjectBulimia
dc.subjectDietary Sucrose
dc.subjectDose-Response Relationship, Drug
dc.subjectDrinking Behavior
dc.subjectDrinking Water
dc.subjectEnergy Intake
dc.subjectHypothalamic Area, Lateral
dc.subjectIntracellular Signaling Peptides and Proteins
dc.subjectMale
dc.subjectMice, Inbred C57BL
dc.subjectMitochondrial Proteins
dc.subjectMotor Activity
dc.subjectNeuropeptides
dc.subjectNeurotransmitter Agents
dc.subjectNuclear Proteins
dc.subjectRNA, Messenger
dc.subjectSaccharin
dc.subjectUrea
dc.titleBinge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL/6J mice: Pharmacological and molecular evidence of orexin involvement
dc.typeArticle


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