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Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure

dc.contributor.authorAndrade D.C.
dc.contributor.authorArce-Alvarez A.
dc.contributor.authorToledo C.
dc.contributor.authorDíaz H.S.
dc.contributor.authorLucero C.
dc.contributor.authorSchultz H.D.
dc.contributor.authorMarcus N.J.
dc.contributor.authorRio R.D.
dc.date.accessioned2020-09-02T22:10:59Z
dc.date.available2020-09-02T22:10:59Z
dc.date.issued2017
dc.identifier10.1152/japplphysiol.00189.2017
dc.identifier.citation123, 3, 567-577
dc.identifier.issn87507587
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3472
dc.descriptionChronic heart failure is characterized by autonomic imbalance, cardiac dysfunction, and arrhythmogenesis. It has been shown that exercise training (ExT) improves central nervous system oxidative stress, autonomic control, and cardiac function in heart failure with reduced ejection fraction; however, to date no comprehensive studies have addressed the effects of ExT, if any, on oxidative stress in brain stem cardiovascular areas, cardiac autonomic balance, arrhythmogenesis, and cardiac function in heart failure with preserved ejection fraction (HFpEF). We hypothesize that ExT reduces brain stem oxidative stress, improves cardiac autonomic control and cardiac function, and reduces arrhythmogenesis in HFpEF rats. Rats underwent sham treatment or volume overload to induce HFpEF. ExT (60 min/day, 25 m/min, 10% inclination) was performed for 6 wk starting at the second week after HFpEF induction. Rats were randomly allocated into Shamsedentary (Sed) (n 8), ShamExT (n 6), HFpEFSed (n 8), and HFpEFExT (n 8) groups. Compared with the HFpEFSed condition, HFpEFExT rats displayed reduced NAD(P)H oxidase activity and oxidative stress in the rostral ventrolateral medulla (RVLM), improved cardiac autonomic balance, and reduced arrhythmogenesis. Furthermore, a threefold improvement in cardiac function was observed in HFpEFExT rats. These novel findings suggest that moderate-intensity ExT is an effective means to attenuate the progression of HFpEF through improvement in RVLM redox state, cardiac autonomic control, and cardiac function. Copyright © 2017 the American Physiological Society.
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.subjectArrhythmogenesis
dc.subjectAutonomic control
dc.subjectExercise training
dc.subjectHeart failure with preserved ejection fraction
dc.subjectanimal
dc.subjectanimal experiment
dc.subjectautonomic nervous system
dc.subjectheart arrhythmia
dc.subjectheart failure
dc.subjectheart left ventricle function
dc.subjectheart rate
dc.subjectheart stroke volume
dc.subjectmale
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpressoreceptor reflex
dc.subjectprocedures
dc.subjectrat
dc.subjectSprague Dawley rat
dc.subjectAnimals
dc.subjectArrhythmias, Cardiac
dc.subjectAutonomic Nervous System
dc.subjectBaroreflex
dc.subjectHeart Failure
dc.subjectHeart Rate
dc.subjectMale
dc.subjectPhysical Conditioning, Animal
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectStroke Volume
dc.subjectVentricular Dysfunction, Left
dc.titleExercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure
dc.typeArticle


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