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Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions

dc.contributor.authorAcaz-Fonseca E.
dc.contributor.authorAvila-Rodriguez M.
dc.contributor.authorGarcia-Segura L.M.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:10:59Z
dc.date.available2020-09-02T22:10:59Z
dc.date.issued2016
dc.identifier10.1016/j.pneurobio.2016.06.002
dc.identifier.citation144, , 5-26
dc.identifier.issn03010082
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3471
dc.descriptionIn the last years there has been a considerable advance in the knowledge on the regulation of astrocytes by sex steroids under physiological and pathological conditions. By the activation of a variety of nuclear and membrane receptors, sex steroid hormones regulate the functions of astrocytes and their communication with other cell types in the central nervous system. Under physiological conditions astrocytes participate in the neuroendocrine and behavioral actions of gonadal steroids, as well as in the hormonal control of brain tissue homeostasis. Under pathological conditions astrocytes mediate, at least partially, the neuroprotective effects of gonadal steroid hormones; given that sex steroids modulate reactive astrogliosis and reduce the release of pro-inflammatory molecules by these cells. Given the side effects that sex steroids may have when administered systemically, a number of synthetic agonists of the receptors for gonadal steroid hormones in the nervous system have been developed, and may be considered for clinical use after brain injury as potential enhancers of the neuroprotective astrocytic functions. © 2016 Elsevier Ltd
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectEstradiol
dc.subjectProgesterone
dc.subjectReactive astrocytes
dc.subjectSex differences
dc.subjectSteroid
dc.subjectTestosterone
dc.subjectandrogen receptor
dc.subjectestradiol
dc.subjectestrogen receptor
dc.subjectprogesterone
dc.subjectprogesterone receptor
dc.subjectselective estrogen receptor modulator
dc.subjectselective tissue estrogenic activity regulator
dc.subjectsex hormone
dc.subjectsteroid hormone
dc.subjectsteroid hormone receptor blocking agent
dc.subjecttestosterone
dc.subjectunclassified drug
dc.subjectsex hormone
dc.subjectastrocyte
dc.subjectastrocytosis
dc.subjectbrain
dc.subjectbrain damage
dc.subjectcells by body anatomy
dc.subjectcentral nervous system
dc.subjectdisease control
dc.subjecthuman
dc.subjectmacroglia
dc.subjectneurobiology
dc.subjectneuroprotection
dc.subjectpriority journal
dc.subjectReview
dc.subjectsex difference
dc.subjectagonists
dc.subjectanimal
dc.subjectBrain Injuries
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectBrain Injuries
dc.subjectGonadal Steroid Hormones
dc.subjectHumans
dc.subjectNeuroprotection
dc.titleRegulation of astroglia by gonadal steroid hormones under physiological and pathological conditions
dc.typeReview


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