ListarInvestigación y Desarrollo por tema "Alzheimer’s disease"
Mostrando ítems 1-20 de 25
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Article
A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet (2024)
(BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the global burden of AD and the advances made in AD drug research and development, the cure of the disease remains elusive, since ... -
Article
Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer’s Disease (2022)
(MDPI, 2022-03)Alzheimer’s disease (AD) is characterized by memory and cognitive impairment, accom-panied by the accumulation of extracellular deposits of amyloid β-peptide (Aβ) and the presence of neurofibrillary tangles (NFTs) composed ... -
Review
APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis (2020)
(Humana Press Inc., 2019) -
Review
Applications of multi-target computer-aided methodologies in molecular design of CNS drugs (2020)
(Bentham Science Publishers B.V., 2018) -
Review
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Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease (2020)
(Humana Press Inc., 2018) -
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Contribution of the nrf2 pathway on oxidative damage and mitochondrial failure in parkinson and alzheimer’s disease (2021)
(MDPI AG, 2021-07)The increase in human life expectancy has become a challenge to reduce the deleterious con-sequences of aging. Nowadays, an increasing number of the population suffer from age-associated neurodegenerative diseases including ... -
Review
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Review
Excitotoxicity as a target against neurodegenerative processes (2020)
(Bentham Science Publishers, 2020) -
Review
Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications (2020)
(SAGE Publications Ltd, 2018) -
Article
Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders (2024)
(Springer, 2024)The gut-brain axis is an essential communication pathway between the central nervous system (CNS) and the gastrointestinal tract. The human microbiota is composed of a diverse and abundant microbial community that compasses ... -
Review
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Review
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Metformin a potential pharmacological strategy in late onset Alzheimer’s disease treatment (2021)
(MDPI, 2021-09)Alzheimer’s disease (AD) is one of the most devastating brain disorders. Currently, there are no effective treatments to stop the disease progression and it is becoming a major public health concern. Several risk factors ... -
Review
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Review
Nanotechnology for Alzheimer disease (2020)
(Bentham Science Publishers B.V., 2017) -
Article
New Drug Design Avenues Targeting Alzheimer’s Disease by Pharmacoinformatics-Aided Tools (2024)
(MDPI, 2022)Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer’s disease (AD) is of special relevance, and despite the ... -
Review
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