Listar Investigación y Desarrollo por autor "Cobo, Ramón"

Mostrando ítems 1-9 de 9

    • Article

      Acid-Sensing Ion Channels’ Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body (2024) 

      Martínez-Barbero, Graciela; García-Mesa, Yolanda; Cobo, Ramón; Cuendias, Patricia; Martín-Biedma, Benjamín; García-Suárez, Olivia; Feito, Jorge; Cobo, Teresa; Vega, José A. (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
      The carotid body is a major peripheral chemoreceptor that senses changes in arterial blood oxygen, carbon dioxide, and pH, which is important for the regulation of breathing and cardiovascular function. The mechanisms by ...
    • Article

      Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy (2023) 

      Cuendias, Patricia; del Rio, Rebeca; García-Suárez, Olivia; Cobo, Ramón; Aragona, Marialuisa; Feito, Jorge; Martín-Biedma, Benjamín; Vega, José A.; García-Mesa, Yolanda (Elsevier GmbH, 2023-03)
      Background: Skin biopsy is a minimally invasive and repeatable technique, applicable in any part of the body that can allows for diagnosis and control of treatments, but to analyze Meissner corpuscles biopsy of glabrous ...
    • Article

      Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity (2020) 

      García-Mesa, Yolanda; Cárcaba, Lucía; Coronado, César A.; Cobo, Ramón; Martín-Cruces, José; García-Piqueras, Jorge; Feito, Jorge; García-Suárez, Olivia; Vega, Jose Antonio (Blackwell Publishing Ltd, 2020-09-29)
      The clitoris is a leading player in female sexual arousal, if not the main protagonist. Despite this role, studies performed on this structure with specific neuroanatomical techniques are few. This study focuses on glans ...
    • Article

      Human digital merkel cells display pannexin1 immunoreactivity (2021) 

      Cárcaba, Lucía; García-Piqueras, Jorge; García-Mesa, Yolanda; Cobo, Ramón; García-Suárez, Olivia; Feito, Jorge; Vega, Jose Antonio (Elsevier GmbH, 2022-01)
      Pannexins are channel proteins displaying functional similarities to gap junctions in vertebrates and are regarded as transmembrane ATP-releasing channels. A member of this family, denominate pannexin1, has been detected ...
    • Article

      Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity (2024) 

      García-Mesa, Yolanda; Martín-Sanz, Raquel; García-Piqueras, Jorge; Cobo, Ramón; Muñoz-Bravo, Saray; García-Suárez, Olivia; Martín-Biedma, Benjamín; Vega, José Antonio; Feito, Jorge (MDPI, 2022)
      As an essential component of mechano-gated ion channels, critically required for mecha-notransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we ...
    • Article

      Peripheral mechanobiology of touch—studies on vertebrate cutaneous sensory corpuscles (2020) 

      Cobo, Ramón; García-Piqueras, Jorge; García-Mesa, Yolanda; Feito, Jorge; García-Suárez, Olivia; Vega, Jose A (MDPI AG, 2020-08-27)
      The vertebrate skin contains sensory corpuscles that are receptors for different qualities of mechanosensitivity like light brush, touch, pressure, stretch or vibration. These specialized sensory organs are linked anatomically ...
    • Article

      Sensory innervation of the human male prepuce: Meissner's corpuscles predominate (2021) 

      García-Mesa, Yolanda; García-Piqueras, Jorge; Cobo, Ramón; Martín-Cruces, José; Suazo, Iván; García-Suárez, Olivia; Feito, Jorge; Vega, Jose Antonio (Blackwell Publishing Ltd, 2021)
      Meissner's corpuscles are the most abundant sensory corpuscles in the glabrous skin of the male prepuce. They are type I, rapidly adapting, low-threshold mechanoreceptors, and their function is linked to the expression of ...
    • Article

      Synaptophysin is a selective marker for axons in human cutaneous end organ complexes (2024) 

      García-Mesa, Yolanda; García-Piqueras, Jorge; Cuendias, Patricia; Cobo, Ramón; Martín-Cruces, José; Feito, Jorge; García-Suarez, Olivia; Biedma, Benjamín Martín; Vega, J.A. (Elsevier GmbH, 2022)
      Background: Small clear synaptic-like vesicles fill axon terminals of mechanoreceptors. Their functional significance is controversial and probably includes release of neurotransmitters from afferent axon terminals. ...
    • Article

      Verification and characterisation of human digital Ruffini’s sensory corpuscles (2020) 

      Cobo, Ramón; García‐Mesa, Yolanda; Cárcaba, Lucía; Martin‐Cruces, José; Feito, Jorge; García‐Suárez, Olivia; Cobo, Juan; García‐Piqueras, Jorge; Vega, José A. (Blackwell Publishing Ltd, 2020-08-31)
      Ruffini's corpuscles are present as long fusiform encapsulated sensory structures in different tissues including the skin. Although physiological analyses strongly suggest their existence in glabrous digital skin, such ...