Listar Investigación y Desarrollo por autor "Camins, Antoni"

Mostrando ítems 1-9 de 9

    • Article

      A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet (2024) 

      Espinosa-Jiménez, Triana; Cano, Amanda; Sánchez-López, Elena; Olloquequi, Jordi; Folch, Jaume; Bulló, Mònica; Verdaguer, Ester; Auladell, Carme; Pont, Caterina; Muñoz-Torrero, Diego; ... (BioMed Central Ltd, 2023)
      Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the global burden of AD and the advances made in AD drug research and development, the cure of the disease remains elusive, since ...
    • Article

      Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities (2024) 

      Pérez, Rebeca; Burgos, Viviana; Marín, Víctor; Camins, Antoni; Olloquequi, Jordi; González-Chavarría, Iván; Ulrich, Henning; Wyneke, Ursula; Luarte, Alejandro; Ortiz, Leandro; ... (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
      Neurodegenerative disorders are characterized by a progressive process of degeneration and neuronal death, where oxidative stress and neuroinflammation are key factors that contribute to the progression of these diseases. ...
    • Article

      Dual mkk4 and mkk7 gene deletion in adult mouse causes an impairment of hippocampal immature granule cells (2021) 

      Castro-Torres, Rubén Darío; Olloquequi, Jordi; Etchetto, Miren; Caruana, Pablo; Steele, Luke; Leighton, Kyra Mae; Ureña, Jesús Mariano; Beas Zárate, C.; Camins, Antoni; Verdaguer, Ester; ... (MDPI, 2021-09)
      (1) Background: The c-Jun-NH2-terminal protein kinase (JNK) is a mitogen-activated protein kinase involved in regulating physiological processes in the central nervous system. However, the dual genetic deletion of Mkk4 and ...
    • Article

      Impact of New Drugs for Therapeutic Intervention in Alzheimer’s Disease (2024) 

      Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Sanchez-López, Elena; Carrasco, Marina; Espinosa, Triana; Beas-Zarate, Carlos; Gudiño-Cabrera, Graciela; Ureña-Guerrero, Monica E.; Verdaguer, Ester; ... (Bioscience Research Institute, 2022)
      The increases in population ageing and growth are leading to a boosting in the number of people living with dementia, Alzheimer’s disease (AD) being the most common cause. In spite of decades of intensive research, no cure ...
    • Article

      JNK signaling and its impact on neural cell maturation and differentiation (2024) 

      Castro-Torres, Rubén D.; Olloquequi, Jordi; Parcerisas, Antoni; Ureña, Jesús; Ettcheto, Miren; Beas-Zarate, Carlos; Camins, Antoni; Verdaguer, Ester; Auladell, Carme (Elsevier Inc., 2024)
      C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and cancer progression. However, JNKs serve key roles ...
    • Article

      JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function (2024) 

      Busquets, Oriol; Espinosa-Jiménez, Triana; Ettcheto, Miren; Olloquequi, Jordi; Bulló, Mònica; Carro, Eva; Cantero, José Luis; Casadesús, Gemma; Folch, Jaume; Verdaguer, Ester; ... (BioMed Central Ltd, 2022)
      Background and aim: The appearance of alterations in normal metabolic activity has been increasingly considered a risk factor for the development of sporadic and late-onset neurodegenerative diseases. In this report, we ...
    • Article

      Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment (2024) 

      Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, Ana; Bicker, Joana; Sánchez-Lopez, Elena; Paz, Cristian; Ureña, Jesús; Verdaguer, Ester; Auladell, Carme; ... (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
      Licochalcone A (Lico-A) is a flavonoid compound derived from the root of the Glycyrrhiza species, a plant commonly used in traditional Chinese medicine. While the Glycyrrhiza species has shown promise in treating various ...
    • Article

      Metformin a potential pharmacological strategy in late onset Alzheimer’s disease treatment (2021) 

      Poor, Saghar Rabiei; Ettcheto, Miren; Cano, Amanda; Sánchez-López, Elena; Manzine, Patricia Regina; Olloquequi, Jordi; Camins, Antoni; Javan, Mohammad (MDPI, 2021-09)
      Alzheimer’s disease (AD) is one of the most devastating brain disorders. Currently, there are no effective treatments to stop the disease progression and it is becoming a major public health concern. Several risk factors ...
    • Article

      Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders (2024) 

      Olloquequi, Jordi; Cano, Amanda; Sanchez-López, Elena; Carrasco, Marina; Verdaguer, Ester; Fortuna, Ana; Folch, Jaume; Bulló, Mònica; Auladell, Carme; Camins, Antoni; ... (Elsevier Masson s.r.l., 2022)
      Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and receptor-associated tyrosine kinases. This widely localized enzyme has been ...