ListarArtículos científicos por tema "Tau"
Mostrando ítems 1-13 de 13
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A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet (2024)
(BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the global burden of AD and the advances made in AD drug research and development, the cure of the disease remains elusive, since ... -
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Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer’s Disease (2022)
(MDPI, 2022-03)Alzheimer’s disease (AD) is characterized by memory and cognitive impairment, accom-panied by the accumulation of extracellular deposits of amyloid β-peptide (Aβ) and the presence of neurofibrillary tangles (NFTs) composed ... -
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Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore (2024)
(Elsevier B.V., 2024)Mitochondrial dysfunction is a significant factor in the development of Alzheimer's disease (AD). Previous studies have demonstrated that the expression of tau cleaved at Asp421 by caspase-3 leads to mitochondrial abnormalities ... -
Article
Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease (2020)
(Humana Press Inc., 2018) -
Review
Contribution of Tau pathology to mitochondrial impairment in neurodegeneration (2020)
(Frontiers Media S.A., 2018) -
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Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome (2020)
(BioMed Central Ltd., 2018) -
Review
It's all about tau (2020)
(Elsevier Ltd, 2019) -
Article
Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging (2024)
(Elsevier Inc., 2024)Current studies indicate that pathological modifications of tau are associated with mitochondrial dysfunction, synaptic failure, and cognitive decline in neurological disorders and aging. We previously showed that caspase-3 ... -
Review
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Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons (2020)
(Academic Press Inc., 2014) -
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The role of mitochondrial impairment in alzheimer´s disease neurodegeneration: The Tau connection (2020)
(Bentham Science Publishers, 2020)Accumulative evidence has shown that mitochondrial dysfunction plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial impairment actively contributes to the synaptic and cognitive failure that ...