Listar Artículos científicos por autor "Johnson, Gail V.W."
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Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore (2024)
Pérez, María José; Ibarra-García-Padilla, Rodrigo; Tang, Maoping; Porter, George A.; Johnson, Gail V.W.; Quintanilla, Rodrigo A. (Elsevier B.V., 2024)Mitochondrial dysfunction is a significant factor in the development of Alzheimer's disease (AD). Previous studies have demonstrated that the expression of tau cleaved at Asp421 by caspase-3 leads to mitochondrial abnormalities ... -
Article
Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging (2024)
Olesen, Margrethe A.; Pradenas, Eugenia; Villavicencio-Tejo, Francisca; Porter, George A.; Johnson, Gail V.W.; Quintanilla, Rodrigo A. (Elsevier Inc., 2024)Current studies indicate that pathological modifications of tau are associated with mitochondrial dysfunction, synaptic failure, and cognitive decline in neurological disorders and aging. We previously showed that caspase-3 ...