• Article

      Hydrochlorothiazide Reduces Cardiac Hypertrophy, Fibrosis and Rho-Kinase Activation in DOCA-Salt Induced Hypertension (2021) 

      Mondaca-Ruff, David; Araos, Patricio; Yañez, Cristián E.; Novoa, Ulises F.; Mora, Italo G.; Ocaranza, María Paz; Jalil, Jorge E. (SAGE Publications Ltd, 2021)
      Background: Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothiazide (HCTZ) is the most frequently used diuretic for hypertension treatment. The Rho/Rho-kinase ...
    • Article

      Low-Chloride Diet Prevents the Development of Arterial Hypertension and Protects Kidney Function in Angiotensin II-Infused Mice (2024) 

      Liberona, Jessica; Araos, Patricio; Rodríguez, Marcelo; León, Pablo; Stutzin, Andrés; Alzamora, Rodrigo; Michea, Luis (S. Karger AG, 2024)
      Introduction: A comprehensive pathophysiological mechanism to explain the relationship between high-salt intake and hypertension remains undefined. Evidence suggests that chloride, as the accompanying anion of sodium in ...
    • Article

      Neutrophil gelatinase–associated lipocalin as an immunomodulator in endocrine hypertension (2024) 

      Araos, Patricio; Amador, Cristián A. (Frontiers Media S.A., 2022)
      In recent studies, primary aldosteronism (PA) has been reported as the most common etiology for secondary hypertension of endocrine origin, accounting for approximately 10% of cases. In PA, excess aldosterone production ...
    • Article

      Oxidized albumin as a mediator of kidney disease (2021) 

      Figueroa, Stefanny M.; Araos, Patricio; Reyes, Javier; Gravez, Basile; Barrera-Chimal, Jonatan; Amador, Cristián A. (MDPI AG, 2021-03)
      Renal diseases are a global health concern, and nearly 24% of kidney disease patients are overweight or obese. Particularly, increased body mass index has been correlated with oxidative stress and urinary albumin excretion ...
    • Article

      Role of inflammation in hypertension (2021) 

      Prat, Hernán; Araos, Patricio; Michea, Luis F. (Sociedad Medica de Santiago, 2021-02)
      Even though the mechanisms that mediate essential hypertension (HT) are not fully understood, an immunological-inflammatory mechanism could be the common pathway for diverse pathophysiological mechanisms. We analyze in a ...
    • Article

      The role of neutrophils in hypertension (2020) 

      Araos, Patricio; Figueroa, Stefanny; Amador, Cristián A. (MDPI AG, 2020-11-02)
      It is well accepted that the immune system and some cells from adaptive and innate immunity are necessary for the initiation/perpetuation of arterial hypertension (AH). However, whether neutrophils are part of this group ...