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5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a new family of task-3 channel blockers: A pharmacophore-based regioselective synthesis (2021)
(MDPI AG, 2021-07-01)
TASK channels belong to the two-pore-domain potassium (K2P) channels subfamily. These channels modulate cellular excitability, input resistance, and response to synaptic stimulation. TASK-channel inhibition led to membrane ...
A method to estimate the efficacy vs effectiveness in meta-analysis of clinical trials with different adherence scenarios: A Monte Carlo simulation study in nutrition (2021)
(MDPI AG, 2021-07)
Randomized clinical trials (RCTs) evaluating the effectiveness of interventions to promote fruit and vegetable (FV) consumption usually report intention-to-treat (ITT) analysis as the main outcome. These analyses compare ...
Factor analysis of the cross-cultural adaptation of the Multidimensional Attitudes Scale towards Deaf persons in Chilean dental students (2021)
(Piracicaba Dental School - UNICAMP, 2021)
There are various instruments to measure attitudes toward persons with disabilities (PwD). The Multidimensional Attitudes Scale (MAS) toward PwD is a three-dimension scale with good psychometric properties; the Spanish ...
Mobility controversies: The case of the chacao bridge, chiloé archipelago southern chile (2021)
(Pontificia Universidade Catolica do Parana, 2021)
In recent decades, the mobility practices of the inhabitants of Chiloé have been influenced by the installation of various types of infrastructure, which has an impact on the socio-economic, cultural and political spheres, ...
Nosology, prophylaxis and legal medical value of sexually transmitted infections in rape processes in Chile (1890-1920) (2021)
(CSIC Consejo Superior de Investigaciones Cientificas, 2021)
Since the second half of the 19th century, the growing development of the medical-hygienist movement and its indissoluble combination with the eugenics movement, promoted in Chile the gradual institutional implementation ...
Functions and Importance of Incorporation Control, with Special Mention to the Contracting of Financial Products and Financial Services (2021)
(Universidad Austral de Chile, 2021)
The present paper examines the control of incorporation of individually non-negotiated clauses, highlighting the special importance that it acquires in the field of contracting financial products and services. For these ...
4-Oxoquinolines and monoamine oxidase: When tautomerism matters (2021)
(Elsevier Masson s.r.l., 2021-03-05)
4-Oxoquinoline derivatives have been often used in drug discovery programs due to their pharmacological properties. Inspired on chromone and 4-oxoquinoline chemical structure similarity, a small series of quinoline-based ...
Impact of spectators’ perceptions of corporate social responsibility on regional attachment in sports: Three-wave indirect effects of spectators’ pride and team identification (2021)
(MDPI AG, 2021-01-02)
The professional sports events industry is becoming immensely popular due to a global social shift toward larger numbers of spectators at sports events and an ever-increasing variety of such events. This study aimed to ...
Structure-antioxidant activity relationships in boldine and glaucine: a DFT study (2021)
(Royal Society of Chemistry, 2021-01-14)
Previous experimental results on the free radical-scavenging properties of boldine, one of the most potent natural antioxidants, suggested that the benzylic hydrogen, neighboring a nitrogen lone electron pair, might be the ...
Relativistic effects on dative carbon-coinage metal bond. Evaluation of NHC-MCl (M = Cu, Ag, Au) from relativistic DFT (2021)
(Elsevier Ltd, 2021-03-15)
The use of different N-heterocyclic carbene (NHC) as dative ligands benefits from their capabilities ranging from strong to weak σ-donor according to the Tolman electronic parameter (TEP), well spread in the formation of ...