Listar Producción Científica por autor "González, Wendy"
Mostrando ítems 1-3 de 3
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Article
5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a new family of task-3 channel blockers: A pharmacophore-based regioselective synthesis (2021)
Ramírez, David; Mejiá-Gutiérrez, Melissa; Insuasty O, Braulio; Rinné, Susanne; Kiper, Aytuğ K.; Platzk, Magdalena; Müller, Thomas; Decher, Niels; Quiroga, Jairo; De la Torre, Pedro; ... (MDPI AG, 2021-07-01)TASK channels belong to the two-pore-domain potassium (K2P) channels subfamily. These channels modulate cellular excitability, input resistance, and response to synaptic stimulation. TASK-channel inhibition led to membrane ... -
Article
A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels (2024)
Valdés-Jiménez, Alejandro; Jiménez-González, Daniel; Kiper, Aytug K.; Rinné, Susanne; Decher, Niels; González, Wendy; Reyes-Parada, Miguel; Núñez-Vivanco, Gabriel (Frontiers Media S.A., 2022)The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable ... -
Article
Identification of a critical binding site for local anaesthetics in the side pockets of Kv1 channels (2021)
Kiper, Aytuğ K.; Bedoya, Mauricio; Stalke, Sarah; Marzian, Stefanie; Ramírez, David; de la Cruz, Alicia; Peraza, Diego A; Vera-Zambrano, Alba; Márquez Montesinos, José C.E.; Arévalo Ramos, Bárbara A.; ... (John Wiley and Sons Inc, 2021)Background and Purpose: Local anaesthetics block sodium and a variety of potassium channels. Although previous studies identified a residue in the pore signature sequence together with three residues in the S6 segment as ...