• Article

      Acid-Sensing Ion Channels’ Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body (2024) 

      Martínez-Barbero, Graciela; García-Mesa, Yolanda; Cobo, Ramón; Cuendias, Patricia; Martín-Biedma, Benjamín; García-Suárez, Olivia; Feito, Jorge; Cobo, Teresa; Vega, José A. (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
      The carotid body is a major peripheral chemoreceptor that senses changes in arterial blood oxygen, carbon dioxide, and pH, which is important for the regulation of breathing and cardiovascular function. The mechanisms by ...
    • Article

      Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy (2023) 

      Cuendias, Patricia; del Rio, Rebeca; García-Suárez, Olivia; Cobo, Ramón; Aragona, Marialuisa; Feito, Jorge; Martín-Biedma, Benjamín; Vega, José A.; García-Mesa, Yolanda (Elsevier GmbH, 2023-03)
      Background: Skin biopsy is a minimally invasive and repeatable technique, applicable in any part of the body that can allows for diagnosis and control of treatments, but to analyze Meissner corpuscles biopsy of glabrous ...
    • Article

      Exploring somatosensory innervation of the human lip: A focus on the vermilion (2024) 

      Martín-Cruces, José; Martín-Biedma, Benjamín; García-Mesa, Yolanda; Cuendias, Patricia; Gaite, Juan J.; García-Suárez, Olivia; Cobo, Juan L.; Vega, José A. (Elsevier GmbH, 2023)
      Background: The lips are a vital component of the face and are densely innervated to perform various functions. The lip edges are covered with mucocutaneous tissue called vermilion which is particularly receptive to touch ...
    • Article

      Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity (2020) 

      García-Mesa, Yolanda; Cárcaba, Lucía; Coronado, César A.; Cobo, Ramón; Martín-Cruces, José; García-Piqueras, Jorge; Feito, Jorge; García-Suárez, Olivia; Vega, Jose Antonio (Blackwell Publishing Ltd, 2020-09-29)
      The clitoris is a leading player in female sexual arousal, if not the main protagonist. Despite this role, studies performed on this structure with specific neuroanatomical techniques are few. This study focuses on glans ...
    • Article

      Human digital merkel cells display pannexin1 immunoreactivity (2021) 

      Cárcaba, Lucía; García-Piqueras, Jorge; García-Mesa, Yolanda; Cobo, Ramón; García-Suárez, Olivia; Feito, Jorge; Vega, Jose Antonio (Elsevier GmbH, 2022-01)
      Pannexins are channel proteins displaying functional similarities to gap junctions in vertebrates and are regarded as transmembrane ATP-releasing channels. A member of this family, denominate pannexin1, has been detected ...
    • Article

      Immunohistochemical detection of PIEZO1 and PIEZO2 in human digital Meissner´s corpuscles (2024) 

      García-Mesa, Yolanda; Cuendias, Patricia; Alonso-Guervós, Marta; García-Piqueras, Jorge; Martín-Biedma, Benjamín; Cobo, Teresa; García-Suárez, Olivia; Vega, José A. (Elsevier GmbH, 2024)
      Background: The cutaneous end organ complexes or cutaneous sensory corpuscles are specialized sensory organs associated to low-threshold mechanoreceptors. Mechano-gated proteins forming a part of ion channels have been ...
    • Article

      Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament (2024) 

      Gaite, Juan J.; Solé-Magdalena, Antonio; García-Mesa, Yolanda; Cuendias, Patricia; Martin-Cruces, José; García-Suárez, Olivia; Cobo, Teresa; Vega, José A.; Martín-Biedma, Benjamín (John Wiley and Sons Inc, 2023)
      PIEZO1 and PIEZO2 are essential components of mechanogated ion channels, which are required for mechanotransduction and biological processes associated with mechanical stimuli. There is evidence for the presence of PIEZO1 ...
    • Article

      Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity (2024) 

      García-Mesa, Yolanda; Martín-Sanz, Raquel; García-Piqueras, Jorge; Cobo, Ramón; Muñoz-Bravo, Saray; García-Suárez, Olivia; Martín-Biedma, Benjamín; Vega, José Antonio; Feito, Jorge (MDPI, 2022)
      As an essential component of mechano-gated ion channels, critically required for mecha-notransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we ...
    • Article

      Peripheral mechanobiology of touch—studies on vertebrate cutaneous sensory corpuscles (2020) 

      Cobo, Ramón; García-Piqueras, Jorge; García-Mesa, Yolanda; Feito, Jorge; García-Suárez, Olivia; Vega, Jose A (MDPI AG, 2020-08-27)
      The vertebrate skin contains sensory corpuscles that are receptors for different qualities of mechanosensitivity like light brush, touch, pressure, stretch or vibration. These specialized sensory organs are linked anatomically ...
    • Article

      Proprioceptive innervation of the human lips (2024) 

      Martín-Cruces, José; Cuendias, Patricia; García-Mesa, Yolanda; Cobo, Juan L.; García-Suárez, Olivia; Gaite, Juan J.; Vega, José A.; Martín-Biedma, Benjamín (John Wiley and Sons Inc, 2024)
      The objective of this study was to analyze the proprioceptive innervation of human lips, especially of the orbicularis oris muscle, since it is classically accepted that facial muscles lack typical proprioceptors, that is, ...
    • Article

      Retinal protection from LED-backlit screen lights by short wavelength absorption filters (2021) 

      Sánchez-Ramos, Celia; Bonnin-Arias, Cristina; Blázquez-Sánchez, Vanesa; Aguirre-Vilacoro, Victoria; Cobo, Teresa; García-Suárez, Olivia; Pérez-Carrasco, María Jesús; Alvarez-Peregrina, Cristina; Vega, Jose Antonio (MDPI, 2021-11)
      Background: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and ...
    • Article

      Sensory innervation of the human male prepuce: Meissner's corpuscles predominate (2021) 

      García-Mesa, Yolanda; García-Piqueras, Jorge; Cobo, Ramón; Martín-Cruces, José; Suazo, Iván; García-Suárez, Olivia; Feito, Jorge; Vega, Jose Antonio (Blackwell Publishing Ltd, 2021)
      Meissner's corpuscles are the most abundant sensory corpuscles in the glabrous skin of the male prepuce. They are type I, rapidly adapting, low-threshold mechanoreceptors, and their function is linked to the expression of ...
    • Article

      Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis (2024) 

      García-Martínez, Irene; García-Mesa, Yolanda; García-Piqueras, Jorge; Martínez-Pubil, Antonio; Cobo, Juan L.; Feito, Jorge; García-Suárez, Olivia; Vega, José A. (John Wiley and Sons Inc, 2022)
      The human palmar aponeurosis is involved in hand proprioception, and it contains different sensory corpuscle morphotypes that serve this role. In palmar fibromatosis (classically referred to as Dupuytren's disease), the ...
    • Article

      Sensory innervation of the human shoulder joints in healthy and in chronic pain shoulder syndromes (2024) 

      Martínez-Gago, Abel; García-Mesa, Yolanda; Cuendias, Patricia; Martín-Cruces, José; Abellán, Juan F.; García-Suárez, Olivia; Vega, José A. (Elsevier GmbH, 2024)
      Background: Afferent innervation of shoulder joints plays a fundamental role in nociception and mechanoception and its alteration result in shoulder´s disease that course with pain and functional disability. Methods: Joints ...
    • Article

      The acquisition of mechanoreceptive competence by human digital Merkel cells and sensory corpuscles during development: An immunohistochemical study of PIEZO2 (2022) 

      García-Mesa, Yolanda; Feito, Jorge; Cuendias, Patricia; García-Piqueras, Jorge; Germanà, Antonino; García-Suárez, Olivia; Martín-Biedma, Benjamín; Vega, José A. (Elsevier GmbH, 2022-08)
      Background: PIEZO2 is a transmembrane protein forming part of an ion channel required for mechanotransduction. In humans, PIEZO2 is present in axon terminals of adult Meissner and Pacinian corpuscles, as well as Merkel ...
    • Article

      The Lamellar Cells of Vertebrate Meissner and Pacinian Corpuscles: Development, Characterization, and Functions (2024) 

      Suazo, Iván; Vega, José A.; García-Mesa, Yolanda; García-Piqueras, Jorge; García-Suárez, Olivia; Cobo, Teresa (Frontiers Media S.A., 2022)
      Sensory corpuscles, or cutaneous end-organ complexes, are complex structures localized at the periphery of Aβ-axon terminals from primary sensory neurons that primarily work as low-threshold mechanoreceptors. Structurally, ...