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Daily steps and all-cause mortality: An umbrella review and meta-analysis
dc.contributor.author | Rodríguez-Gutiérrez, Eva | |
dc.contributor.author | Torres-Costoso, Ana | |
dc.contributor.author | del Pozo Cruz, Borja | |
dc.contributor.author | de Arenas-Arroyo, Sergio Núñez | |
dc.contributor.author | Pascual-Morena, Carlos | |
dc.contributor.author | Bizzozero-Peroni, Bruno | |
dc.contributor.author | Martínez-Vizcaíno, Vicente | |
dc.date.accessioned | 2024-07-23T19:34:08Z | |
dc.date.available | 2024-07-23T19:34:08Z | |
dc.date.issued | 2024 | |
dc.identifier | 10.1016/j.ypmed.2024.108047 | |
dc.identifier.issn | 00917435 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/11591 | |
dc.description.abstract | Objective: This study aimed to describe the variability in estimates of the association of daily steps and all-cause mortality in systematic reviews with meta-analyses, to identify the factors potentially responsible for it, and to provide an updated estimate. Methods: Five databases were systematically searched up to May 2024 to identify systematic reviews with meta-analyses and prospective cohort studies. A qualitative synthesis of previous reviews and an updated meta-analysis of cohort studies were performed. Pooled hazard ratios (HRs) with their 95% confidence intervals (CIs) were calculated using a random-effects model. Results: Eleven systematic reviews with meta-analyses and 14 cohort studies were included, revealing considerable variability in result presentation. Our updated meta-analysis showed a nonlinear association, indicating a lower risk of all-cause mortality with increased daily steps, with a protective threshold at 3143 steps/day, and a pooled HR of 0.91 (95% CI: 0.87, 0.95) per 1000 steps/day increment. Physical activity categories consistently indicated progressively reduced mortality risk, with the highly active category (>12,500 steps/day) exhibiting the lowest risk (0.35 (95% CI: 0.29, 0.42)). Conclusion: Systematic reviews and meta-analyses showed considerable variability in effect estimates due to different methods of quantifying exposure. Despite it, our study underscores the importance of increased daily steps in reducing all-cause mortality, with a minimum protective dose of 3000 steps/day, although the optimal dose differed according to age and sex. It is recommended that future studies categorise daily steps by physical activity category, perform dose-response analyses, and use increments of 1000 steps/day. © 2024 The Authors | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III, ISCIII; Ministerio de Economía y Competitividad, MINECO; Universidad de Castilla-La Mancha, UCLM; Ministry of Economy and Competitiveness-Carlos III Health Institute; FEDER, (RD21/0016/0025); European Commission, EC, (2022-UNIVERS-11373, 2020-PREDUCLM-16704); European Commission, EC; European Social Fund Plus, ESF, (2020-PREDUCLM-16746); European Social Fund Plus, ESF | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Academic Press Inc. | es_ES |
dc.subject | Daily steps | es_ES |
dc.subject | Death | es_ES |
dc.subject | Dose response | es_ES |
dc.subject | Physical activity | es_ES |
dc.subject | Step count | es_ES |
dc.subject | Wearable | es_ES |
dc.title | Daily steps and all-cause mortality: An umbrella review and meta-analysis | es_ES |
dc.type | Article | es_ES |