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The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis
dc.contributor.author | Turner, Laurent | |
dc.contributor.author | Charrouf, Rasha | |
dc.contributor.author | Martínez-Vizcaíno, Vicente | |
dc.contributor.author | Hutchison, Amy | |
dc.contributor.author | Heilbronn, Leonie K. | |
dc.contributor.author | Fernández-Rodríguez, Rubén | |
dc.date.accessioned | 2024-06-21T20:18:43Z | |
dc.date.available | 2024-06-21T20:18:43Z | |
dc.date.issued | 2024 | |
dc.identifier | 10.4067/S0717-95022024000100021 | |
dc.identifier.issn | 00029165 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/11533 | |
dc.description.abstract | Background: Time-restricted eating (TRE) may facilitate weight loss, but its impact on inflammation remains unclear. Chronic inflammation can detrimentally increase risk of obesity-associated comorbidities. Objectives: The aim of this systematic review was to synthesize and determine the effects of TRE on cytokine and adipokines (C-reactive protein [CRP], TNF alpha [TNF-α], interleukin-6 [IL-6], leptin, and adiponectin) in adults. Methods: PubMed, Scopus, Cochrane CENTRAL, and Web of Science were systematically searched for randomized controlled trials (RCTs) and non-RCTs to determine the effects of TRE on cytokines and adipokines in adults up to 23 June, 2023. Risk of bias was assessed using risk of Bias 2 tool for RCTs and the ROBINS-I for non-RCTs. The standardized mean differences (SMDs) and their 95% confidence intervals (CIs) were estimated with the DerSimonian–Laird method through random-effect models. The PRISMA recommendations were followed. Results: A total of 25 studies (13 RCTs, 12 non-RCTs) involving 936 participants were included. The pooled SMD for the effect of TRE compared with the control group on cytokines and adipokines was −0.11 (95% CI: −0.33, 0.12; I2 = 19.7%; n = 10 comparisons) for CRP; −0.25 (95% CI: −0.47, −0.03; I2 = 0%; n = 11 comparisons) for TNF-α; −0.09 (95% CI: −0.39, 0.21; I2 = 16.4%; n = 8 comparisons) for IL-6; −0.81 (95% CI: −1.37, −0.24; I2 = 65.3%; n = 5 comparisons) for leptin; and 0.07 (95% CI: −0.40, 0.54; I2 = 56.9%; n = 6 comparisons) for adiponectin. Conclusions: Time-restricted eating may be an effective approach to reduce TNF-α and leptin levels in the general adult population. This review was registered at PROSPERO as CRD42022358162. © 2023 American Society for Nutrition | es_ES |
dc.description.sponsorship | University of Adelaide; Ministerio de Educación, Cultura y Deporte, MECD, (FPU 19/00167) | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Elsevier B.V. | es_ES |
dc.subject | adipokines | es_ES |
dc.subject | cytokines | es_ES |
dc.subject | inflammation | es_ES |
dc.subject | time-restricted eating | es_ES |
dc.title | The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis | es_ES |
dc.type | Article | es_ES |