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Dynamics of Gut Microbiota and Short-Chain Fatty Acids during a Cycling Grand Tour Are Related to Exercise Performance and Modulated by Dietary Intake
dc.contributor.author | Fernandez-Sanjurjo, Manuel | |
dc.contributor.author | Fernandez, Javier | |
dc.contributor.author | Martinez-Camblor, Pablo | |
dc.contributor.author | Rodriguez-Alonso, Manuel | |
dc.contributor.author | Ortolano-Rios, Raquel | |
dc.contributor.author | Pinto-Hernandez, Paola | |
dc.contributor.author | Castilla-Silgado, Juan | |
dc.contributor.author | Coto-Vilcapoma, Almudena | |
dc.contributor.author | Ruiz, Lorena | |
dc.contributor.author | Villar, Claudio J. | |
dc.contributor.author | Tomas-Zapico, Cristina | |
dc.contributor.author | Margolles, Abelardo | |
dc.contributor.author | Fernandez-Garcia, Benjamin | |
dc.contributor.author | Iglesias-Gutierrez, Eduardo | |
dc.contributor.author | Lombó, Felipe | |
dc.date.accessioned | 2024-06-21T20:16:38Z | |
dc.date.available | 2024-06-21T20:16:38Z | |
dc.date.issued | 2024 | |
dc.identifier | 10.3390/nu16050661 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/11522 | |
dc.description.abstract | Background: Regular exercise has been described to modify both the diversity and the relative abundance of certain bacterial taxa. To our knowledge, the effect of a cycling stage race, which entails extreme physiological and metabolic demands, on the gut microbiota composition and its metabolic activity has not been analysed. Objective: The aim of this cohort study was to analyse the dynamics of faecal microbiota composition and short-chain fatty acids (SCFAs) content of professional cyclists over a Grand Tour and their relationship with performance and dietary intake. Methods: 16 professional cyclists competing in La Vuelta 2019 were recruited. Faecal samples were collected at four time points: the day before the first stage (A); after 9 stages (B); after 15 stages (C); and on the last stage (D). Faecal microbiota populations and SCFA content were analysed using 16S rRNA sequencing and gas chromatography, respectively. A principal component analysis (PCA) followed by Generalised Estimating Equation (GEE) models were carried out to explore the dynamics of microbiota and SCFAs and their relationship with performance. Results: Bifidobacteriaceae, Coriobacteriaceae, Erysipelotrichaceae, and Sutterellaceae dynamics showed a strong final performance predictive value (r = 0.83, ranking, and r = 0.81, accumulated time). Positive correlations were observed between Coriobacteriaceae with acetate (r = 0.530) and isovalerate (r = 0.664) and between Bifidobacteriaceae with isobutyrate (r = 0.682). No relationship was observed between SCFAs and performance. The abundance of Erysipelotrichaceae at the beginning of La Vuelta was directly related to the previous intake of complex-carbohydrate-rich foods (r = 0.956), while during the competition, the abundance of Bifidobacteriaceae was negatively affected by the intake of simple carbohydrates from supplements (r = −0.650). Conclusions: An ecological perspective represents more realistically the relationship between gut microbiota composition and performance compared to single-taxon approaches. The composition and periodisation of diet and supplementation during a Grand Tour, particularly carbohydrates, could be designed to modulate gut microbiota composition to allow better performance. © 2024 by the authors. | es_ES |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades, MCIU; Federación Española de Enfermedades Raras, FEDER; Agencia Estatal de Investigación, AEI, (RTI2018-095021-J-I00); Agencia Estatal de Investigación, AEI; Gobierno del Principado de Asturias, GPA, (AYUD/2021/51347); Gobierno del Principado de Asturias, GPA; Ministerio de Ciencia e Innovación, MCIN, (PID2021-127812OB-I00); Ministerio de Ciencia e Innovación, MCIN | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.subject | exercise performance | es_ES |
dc.subject | metabolomics | es_ES |
dc.subject | metagenomics | es_ES |
dc.subject | prebiotics | es_ES |
dc.subject | probiotics | es_ES |
dc.subject | sports nutrition | es_ES |
dc.title | Dynamics of Gut Microbiota and Short-Chain Fatty Acids during a Cycling Grand Tour Are Related to Exercise Performance and Modulated by Dietary Intake | es_ES |
dc.type | Article | es_ES |