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Parasympathetic cardiac dysautonomia in amyotrophic lateral sclerosis patients
dc.contributor.author | Quarracino, Cecilia | |
dc.contributor.author | Bohórquez Morera, Natalia | |
dc.contributor.author | Capani, Francisco | |
dc.contributor.author | Pérez-Lloret, Santiago | |
dc.contributor.author | Rodríguez, Gabriel Eduardo | |
dc.date.accessioned | 2024-06-19T05:05:42Z | |
dc.date.available | 2024-06-19T05:05:42Z | |
dc.date.issued | 2024 | |
dc.identifier | 10.1016/j.neuarg.2024.03.003 | |
dc.identifier.issn | 18530028 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/11454 | |
dc.description.abstract | Introduction: Although some studies have shown the presence of cardiac dysautonomia in amyotrophic lateral sclerosis (ALS) patients, its relationship with the disease is still controversial. Objective: To explore cardiac dysautonomia in ALS and its possible association with disease evolution and patient's quality of life. Materials and methods: We evaluated demographics and disease-related variables, comorbidities and quality of life in 20 ALS patients. We performed the autonomic symptoms profile and SF-36 (quality of life) scales. Patients were also evaluated with dynamometry, orthostatic testing and RR interval variability (RRIV) in resting and deep breathing electrocardiograms. Twenty age- and gender- matched healthy individuals served as controls for autonomic cardiovascular measurements. Results: The mean age of ALS patients was 52 ± 14 years, 75% were male and 85% had spinal disease onset. The mean score as per the ALS-FRS and FVC were 25.65 ± 10.55 and 67% ± 21, respectively. Cardiac parasympathetic dysautonomia was found in 4 out of 17 (25%) ALS patients vs. none of the controls (P = 0.031). ALS patients with reduced RRIV did not differ statistically in any variably from those without. Only 1 patient (6%) vs. none of the controls had orthostatic hypotension (P = 0.18). Conclusion: Parasympathetic cardiac dysautonomia was observed in 25% of the ALS patients. Lack of association with epidemiological or ALS-related variables suggests a different pathological process. © 2024 Sociedad Neurológica Argentina | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Ediciones Doyma, S.L. | es_ES |
dc.subject | ALS cardiac dysautonomia | es_ES |
dc.subject | Orthostatic hypotension | es_ES |
dc.subject | Parasympathetic cardiac dysautonomia | es_ES |
dc.subject | Reduced RR interval variability | es_ES |
dc.subject | Sympathetic cardiac dysautonomia | es_ES |
dc.title | Parasympathetic cardiac dysautonomia in amyotrophic lateral sclerosis patients | es_ES |
dc.title.alternative | Disautonomía cardíaca parasimpática en pacientes con esclerosis lateral amiotrófica | es_ES |
dc.type | Article | es_ES |