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Lifestyle risk factors and all-cause and cause-specific mortality in the Mexico City prospective study: Assessing the influence of reverse causation
dc.contributor.author | Ferrari, Gerson | |
dc.contributor.author | de Maio Nascimento, Marcelo | |
dc.contributor.author | Petermann-Rocha, Fanny | |
dc.contributor.author | Rezende, Leandro F.M. | |
dc.contributor.author | O'Donovan, Gary | |
dc.contributor.author | Gouveia, Élvio R. | |
dc.contributor.author | Cristi-Montero, Carlos | |
dc.contributor.author | Marques, Adilson | |
dc.date.accessioned | 2024-06-19T04:43:25Z | |
dc.date.available | 2024-06-19T04:43:25Z | |
dc.date.issued | 2024 | |
dc.identifier | 10.1016/j.jad.2024.02.072 | |
dc.identifier.issn | 01650327 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/11334 | |
dc.description.abstract | Background: We examined the association between individual lifestyle risk factors with all-cause and cause-specific mortality. Methods: Prospective cohort study including 155,002 participants from the Mexico City Prospective Study. Cox regression models were used to estimate the association between individual lifestyle risk factors and all-cause and cause-specific mortality. Participants with prevalent diseases at baseline and participants who died during the first 2, 5, 10, and 15 years of follow-up were excluded to account for reverse causation. Results: 27,469 people died during 18.3 years of follow-up years. Overweight and moderate alcohol consumption were inversely associated with all-cause mortality, while low physical activity and smoking were positively associated when all participants were included, regardless of prevalent disease or duration of follow-up. The direction of the association of overweight with all-cause mortality changed from inverse to positive after excluding the first 10 years of follow-up. Compared with normal weight, the hazard ratio (95 % confidence interval) was 1.17 (1.13,1.22) for obesity after excluding those who died in the first 5 years of follow-up and 1.71 (1.59,1.84) after excluding the first 15 years of follow-up. The magnitude of the association of alcohol intake, low physical activity, and smoking with mortality attenuated, whereas for fruits and vegetables increased, after excluding longer periods of follow-up. Limitations: The data were collected exclusively in Mexico City; lifestyle risk factors were self-reported and thus prone to misclassification bias. Conclusions: Reverse causation may influence both the magnitude and the direction of the associations between lifestyle risk factors and mortality. © 2024 Elsevier B.V. | es_ES |
dc.description.sponsorship | Medical Research Council, MRC; Mexican Health Ministry; Consejo Nacional de Ciencia y Tecnología, CONACYT; Wellcome Trust, WT; Vicerrectoría de Investigación y Doctorados, Universidad Autónoma de Chile; Universidad Autónoma de Chile.This, (2022-020) | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Elsevier B.V. | es_ES |
dc.subject | Bias | es_ES |
dc.subject | Lifestyle risk factor | es_ES |
dc.subject | Mortality | es_ES |
dc.subject | Prospective study | es_ES |
dc.subject | Reverse causation | es_ES |
dc.title | Lifestyle risk factors and all-cause and cause-specific mortality in the Mexico City prospective study: Assessing the influence of reverse causation | es_ES |
dc.type | Article | es_ES |